Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid
| Autor: | Hiroichi Kishi, Elaine S. Gilleece, Maria del Pilar Pla, Thomas F. O'Brien, Michael Syvanen, John D. Hopkins, Kenneth H. Mayer |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.drug_class
Antibiotics Gentamicin resistance Microbiology Plasmid medicine Escherichia coli Humans Gene Electrophoresis Agar Gel Multidisciplinary biology Bacteria Drug Resistance Microbial biology.organism_classification Nucleotidyltransferase Nucleotidyltransferases Intestines Genes Bacterial Conjugation Genetic Gentamicin Gentamicins medicine.drug Antibiotic resistance genes Plasmids |
| Zdroj: | Science (New York, N.Y.). 230(4721) |
| ISSN: | 0036-8075 |
| Popis: | Bacteria of different genera isolated at nine medical centers in different parts of the United States and at one center in Venezuela during the first decade of gentamicin usage carried the gentamicin resistance gene 2"-aminoglycoside nucleotidyltransferase on the same transferable plasmid. Such widespread dissemination of a newly observed resistance gene on one plasmid suggests that a new resistance gene may emerge once on a single plasmid, which then carries it to other centers and other plasmids. The resistance gene might, therefore, be contained if detected early. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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