Pregnancy Outcomes after Clinical Recovery from AKI
| Autor: | Ravi Thadhani, Jessica Sheehan Tangren, S. Ananth Karumanchi, Camille E. Powe, Michelle A. Hladunewich, Elizabeth Ankers, Jeffrey L. Ecker, Kate Bramham |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases Kidney Preeclampsia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pre-Eclampsia Risk Factors Pregnancy medicine Humans Clinical Epidemiology Retrospective Studies Gynecology Creatinine Obstetrics business.industry Pregnancy Outcome General Medicine Odds ratio Acute Kidney Injury medicine.disease Confidence interval female genital diseases and pregnancy complications Pregnancy Complications chemistry Nephrology Small for gestational age Female business Body mass index Kidney disease |
| Popis: | The effect of clinically recovered AKI (r-AKI) on future pregnancy outcomes is unknown. We retrospectively studied all women who delivered infants between 1998 and 2007 at Massachusetts General Hospital to assess whether a previous episode of r-AKI associated with subsequent adverse maternal and fetal outcomes, including preeclampsia. AKI was defined as rise in serum creatinine concentration to 1.5-fold above baseline. We compared pregnancy outcomes in women with r-AKI without history of CKD (eGFR>90 ml/min per 1.73 m2 before conception; n=105) with outcomes in women without kidney disease (controls; n=24,640). The r-AKI and control groups had similar prepregnancy serum creatinine measurements (0.70±0.20 versus 0.69±0.10 mg/dl; P=0.36). However, women with r-AKI had increased rates of preeclampsia compared with controls (23% versus 4%; P |
| Databáze: | OpenAIRE |
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