Ethanol effects in an anxiety/defense test battery
| Autor: | Scott M. Weiss, Robert J. Blanchard, D. Caroline Blanchard |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Risk Test battery medicine.medical_specialty Health (social science) medicine.drug_class Anxiety Stimulus (physiology) Audiology Toxicology Fixed sequence Biochemistry Anxiolytic Developmental psychology Eating Behavioral Neuroscience chemistry.chemical_compound Sex Factors medicine Animals Defense Mechanisms Ethanol Behavior Animal General Medicine Grooming Rats Neurology chemistry Test day Female medicine.symptom Psychology Risk assessment Locomotion |
| Zdroj: | Alcohol. 7:375-381 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(90)90019-9 |
| Popis: | Two tests, components of an Anxiety/Defense Test Battery, have been designed to measure risk assessment, inhibition of nondefensive behaviors, and movement arrest, all of which occur in the natural defense patterns of rats to threatening stimuli. In these tests, which used a nonpainful threat stimulus (a cat), ethanol (0.6 and 1.2 g/kg) increased two risk assessment behaviors on an initial test day, and produced a wider pattern of changes in all three patterns on a retest (no cat) day, 5 days later. The pattern of results obtained is compatible with a view that defensive behaviors occur in a fixed sequence with the decreasing intensity of threat an important factor in the transition from one defensive behavior to the next, and with ethanol at these doses producing a mild and relatively nonspecific anxiolytic effect. Comparison of male and female subjects on these tasks also suggested that females are more defensive than males, a finding which agrees with a variety of human anxiety studies but is at variance with previous rodent literature. |
| Databáze: | OpenAIRE |
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