The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study

Autor: Abdulkader M. Albasri, Mohammed A. Elkablawy, Irfan Altaf Ansari, Amal A. Khalil, Ahmed Safar Alhujaily
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Oncology
Adult
Male
P63
medicine.medical_specialty
Cytoplasm
Adenoma
Lymphovascular invasion
Colorectal cancer
Gene Expression
lcsh:Medicine
colorectal cancer
030204 cardiovascular system & hematology
medicine.disease_cause
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Biomarkers
Tumor
Humans
Neoplasm Invasiveness
030212 general & internal medicine
Survival rate
Aged
Proportional Hazards Models
Retrospective Studies
Aged
80 and over
business.industry
Tumor Suppressor Proteins
lcsh:R
General Medicine
Middle Aged
medicine.disease
Survival Rate
stomatognathic diseases
Tumor progression
Lymphatic Metastasis
immunohistochemistry
Immunohistochemistry
Female
Original Article
sense organs
prognosis
business
Carcinogenesis
Colorectal Neoplasms
Transcription Factors
Zdroj: Saudi Medical Journal, Vol 40, Iss 5, Pp 432-439 (2019)
Saudi Medical Journal
ISSN: 1658-3175
0379-5284
Popis: Objectives: To evaluate p63 expression pattern in Saudi colorectal cancer (CRC) patients and correlate that with clinicopathological parameters and its role in carcinogenesis and prognosis. Methods : Archival tumor samples were analyzed by immunohistochemistry for p63 expression in 324 consecutive Saudi patients diagnosed with CRC between January 2006 and December 2017 at the Pathology Department of a tertiary care Hospital, Madinah, Saudi Arabia. Results : P63 over-expression was absent in normal mucosa, while 12.5% cases of adenoma showed its over-expression. In CRC, p63 expression was high in 24.1% of cases. There were no significant correlations between p63 expression and gender, tumor location, tumor size and tumor histologic differentiation. However, high p63 expression revealed a significant correlation with age ( p =0.035), tumor type (p=0.004), American Joint Committee on Cancer stage ( p =0.046), lymph node metastasis ( p =0.006), lymphovascular invasion ( p =0.006), distant metastasis (p=0.049), high Ki67 expression ( p =0.000) and K-ras expression (p=0.002). The Kaplan-Meier analysis revealed a shorter period of survival with p63 over-expression ( p less than 0.001). The Cox-regression model analysis showed that p63 over-expression was an independent prognostic marker in CRC ( p =0.000). Conclusion : P63 expression was increased from normal to adenoma to carcinoma sequence. Moreover, p63 cytoplasmic expression seems to be related to high Ki67 indexing, K-ras expression, advanced tumor stage and poor clinical outcome of CRC. These findings suggest a significant role of cytoplasmic p63 expression in tumor progression and prognosis. Saudi Med J 2019; Vol. 40 (5): 432-439 doi: 10.15537/smj.2019.5.24162 How to cite this article: Albasri AM, Elkablawy MA, Ansari IA, Alhujaily AS, Khalil AA. The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study. Saudi Med J . 2019 May;40(5):432-439. doi: 10.15537/smj.2019.5.24162.
Databáze: OpenAIRE
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