Roles of Se and NO in apoptosis of hepatoma cells
| Autor: | Dongyun Shia, Shijin Liu, Guan-Zhong Liu, Shan-Lin Liu, Yide Hu, Hui-Li Chen |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Kappa-selenocarrageenan
Apoptosis Cell Count Biology Carrageenan Nitric Oxide General Biochemistry Genetics and Molecular Biology Mice Selenium Liver Neoplasms Experimental Organoselenium Compounds Tumor Cells Cultured Animals Humans General Pharmacology Toxicology and Pharmaceutics Fluorescent Dyes chemistry.chemical_classification Glutathione Peroxidase Glutathione peroxidase General Medicine Chromatography Agarose Flow Cytometry Molecular biology digestive system diseases Right axilla Hepatoma cell line chemistry Hepatoma cell |
| Zdroj: | Life sciences. 68(6) |
| ISSN: | 0024-3205 |
| Popis: | Mice inoculated with hepatoma cell (H22) suspension subcutaneously at their right axilla were administered orally with kappa-selenocarrageenan (Se) solution, the inoculated hepatoma's growth was suppressed. Different concentrations of Se solution added in human hepatoma cell line culture could inhibit proliferation and induce apoptosis in hepatoma cells. Meanwhile Se solution could increase the activity of glutathione peroxidase (GSH-Px) in the mice's plasma and the content of NO in the mice's sera and the hepatoma cell culture supernatant as well. Therefore, apoptosis in hepatoma cell induced by Se solution may be associated with the increase in antioxidative activity, the suppression free radical's intervention, and the excessive release of NO by stress. |
| Databáze: | OpenAIRE |
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