Novel indazole skeleton derivatives containing 1,2,3-triazole as potential anti-prostate cancer drugs
| Autor: | Yaquan Cao, Yingxue Yang, Maxwell Ampomah-Wireko, Firas Obaid Arhema Frejat, Hongjin Zhai, Shuo Zhang, Huanhuan Wang, Pu Yang, Qingyan Yuan, Guanlian Wu, Chunli Wu |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Indazoles Dose-Response Relationship Drug Molecular Structure Organic Chemistry Clinical Biochemistry Pharmaceutical Science Prostatic Neoplasms Antineoplastic Agents Apoptosis Triazoles Biochemistry Structure-Activity Relationship Cell Line Tumor Drug Discovery Molecular Medicine Humans Drug Screening Assays Antitumor Molecular Biology Skeleton Cell Proliferation |
| Zdroj: | Bioorganicmedicinal chemistry letters. 64 |
| ISSN: | 1464-3405 |
| Popis: | In this study, a novel batch of indazole containing 1,2,3-triazole agents were designed and synthesized. The antiproliferative activity of target compounds in four human cancer cells, PC-3 (human prostate cancer cell), MCF-7 (human breast cancer cell), HepG-2 (human hepatoma cell) and MGC-803 (human gastric cancer cell), was evaluated by thiazole blue (MTT). In the antiproliferative activity screening, we were surprised to find that most compounds have specific cytotoxicity to PC-3 cancer cells. In particular, 9a has an IC |
| Databáze: | OpenAIRE |
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