Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research

Autor: Dan M. Fliss, Luiz Paulo Kowalski, Pankaj Chaturvedi, Gideon Bachar, P.R. Patel, V. A. Bolzoni, Snehal G. Patel, Jonathan R. Clark, Matthias Kreppel, Chun-Ta Liao, Jatin P. Shah, S. J. Brandao, S. Jonnalagadda, Joachim E. Zöller, Moran Amit, K. T. Robbins, Eran Fridman, Jai Prakash Agarwal, Ardalan Ebrahimi, Claudio Roberto Cernea, Tzu Chen Yen, Ziv Gil, Thomas Shpitzer
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: British Journal of Cancer
ISSN: 1532-1827
0007-0920
Popis: Background: Lymph node density (LND) has previously been reported to reliably predict recurrence risk and survival in oral cavity squamous cell carcinoma (OSCC). This multicenter international study was designed to validate the concept of LND in OSCC. Methods: The study included 4254 patients diagnosed as having OSCC. The median follow-up was 41 months. Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional control and distant metastasis rates were calculated using the Kaplan–Meier method. Lymph node density (number of positive lymph nodes/total number of excised lymph nodes) was subjected to multivariate analysis. Results: The OS was 49% for patients with LND⩽0.07 compared with 35% for patients with LND>0.07 (P0.07 (P
Databáze: OpenAIRE