Electronic cigarettes and insulin resistance in animals and humans: Results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016)
Autor: | Albert D. Osei, Michael J. Blaha, Israel D. Sithu, Sanjay Srivastava, S. M. Iftekhar Uddin, Olusola A. Orimoloye, Mohammadhassan Mirbolouk, Lung Chi Chen, Marina V Malovichko, Daniel J. Conklin, Omar Dzaye |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Cross-sectional study Physiology medicine.medical_treatment Electronic Cigarettes Social Sciences 030204 cardiovascular system & hematology Urine Biochemistry Nicotine Cohort Studies Habits Mice 0302 clinical medicine Endocrinology Surveys and Questionnaires Medicine and Health Sciences Smoking Habits Medicine Psychology Insulin Public and Occupational Health 030212 general & internal medicine Multidisciplinary Vaping Smoking Animal Models Middle Aged 3. Good health Body Fluids Nicotine Addiction Experimental Organism Systems Cohort Homeostatic model assessment Female Anatomy Cohort study medicine.drug Research Article Adult National Health and Nutrition Examination Survey Adolescent Substance-Related Disorders Science Addiction Mouse Models Research and Analysis Methods 03 medical and health sciences Young Adult Insulin resistance Model Organisms Diagnostic Medicine Environmental health Mental Health and Psychiatry Animals Humans Aged Diabetic Endocrinology Behavior Endocrine Physiology business.industry Biology and Life Sciences Glucose Tolerance Test medicine.disease Hormones United States Mice Inbred C57BL Cross-Sectional Studies Glucose Tolerance Tests Animal Studies Insulin Resistance business |
Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 12, p e0226744 (2019) |
ISSN: | 1932-6203 |
Popis: | Background The popularity of electronic cigarettes (E-cigarettes) has risen considerably. Several studies have suggested that nicotine may affect insulin resistance, however, the impact of E-cigarette exposure on insulin resistance, an early measure of cardiometabolic risk, is not known. Methods and results Using experimental animals and human data obtained from 3,989 participants of the United States National Health and Nutrition Examination Survey (NHANES), respectively, we assessed the association between E-cigarette and conventional cigarette exposures and insulin resistance, as modelled using the homeostatic model assessment of insulin resistance (HOMA-IR) and glucose tolerance tests (GTT). C57BL6/J mice (on standard chow diet) exposed to E-cigarette aerosol or mainstream cigarette smoke (MCS) for 12 weeks showed HOMA-IR and GTT levels comparable with filtered air-exposed controls. In the NHANES cohort, there was no significant association between defined tobacco product use categories (non-users; sole E-cigarette users; cigarette smokers and dual users) and insulin resistance. Compared with non-users of e-cigarettes/conventional cigarettes, sole E-cigarette users showed no significant difference in HOMA-IR or GTT levels following adjustment for age, sex, race, physical activity, alcohol use and BMI. Conclusion E-cigarettes do not appear to be linked with insulin resistance. Our findings may inform future studies assessing potential cardiometabolic harms associated with E-cigarette use. |
Databáze: | OpenAIRE |
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