Electronic cigarettes and insulin resistance in animals and humans: Results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016)

Autor: Albert D. Osei, Michael J. Blaha, Israel D. Sithu, Sanjay Srivastava, S. M. Iftekhar Uddin, Olusola A. Orimoloye, Mohammadhassan Mirbolouk, Lung Chi Chen, Marina V Malovichko, Daniel J. Conklin, Omar Dzaye
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Cross-sectional study
Physiology
medicine.medical_treatment
Electronic Cigarettes
Social Sciences
030204 cardiovascular system & hematology
Urine
Biochemistry
Nicotine
Cohort Studies
Habits
Mice
0302 clinical medicine
Endocrinology
Surveys and Questionnaires
Medicine and Health Sciences
Smoking Habits
Medicine
Psychology
Insulin
Public and Occupational Health
030212 general & internal medicine
Multidisciplinary
Vaping
Smoking
Animal Models
Middle Aged
3. Good health
Body Fluids
Nicotine Addiction
Experimental Organism Systems
Cohort
Homeostatic model assessment
Female
Anatomy
Cohort study
medicine.drug
Research Article
Adult
National Health and Nutrition Examination Survey
Adolescent
Substance-Related Disorders
Science
Addiction
Mouse Models
Research and Analysis Methods
03 medical and health sciences
Young Adult
Insulin resistance
Model Organisms
Diagnostic Medicine
Environmental health
Mental Health and Psychiatry
Animals
Humans
Aged
Diabetic Endocrinology
Behavior
Endocrine Physiology
business.industry
Biology and Life Sciences
Glucose Tolerance Test
medicine.disease
Hormones
United States
Mice
Inbred C57BL
Cross-Sectional Studies
Glucose Tolerance Tests
Animal Studies
Insulin Resistance
business
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226744 (2019)
ISSN: 1932-6203
Popis: Background The popularity of electronic cigarettes (E-cigarettes) has risen considerably. Several studies have suggested that nicotine may affect insulin resistance, however, the impact of E-cigarette exposure on insulin resistance, an early measure of cardiometabolic risk, is not known. Methods and results Using experimental animals and human data obtained from 3,989 participants of the United States National Health and Nutrition Examination Survey (NHANES), respectively, we assessed the association between E-cigarette and conventional cigarette exposures and insulin resistance, as modelled using the homeostatic model assessment of insulin resistance (HOMA-IR) and glucose tolerance tests (GTT). C57BL6/J mice (on standard chow diet) exposed to E-cigarette aerosol or mainstream cigarette smoke (MCS) for 12 weeks showed HOMA-IR and GTT levels comparable with filtered air-exposed controls. In the NHANES cohort, there was no significant association between defined tobacco product use categories (non-users; sole E-cigarette users; cigarette smokers and dual users) and insulin resistance. Compared with non-users of e-cigarettes/conventional cigarettes, sole E-cigarette users showed no significant difference in HOMA-IR or GTT levels following adjustment for age, sex, race, physical activity, alcohol use and BMI. Conclusion E-cigarettes do not appear to be linked with insulin resistance. Our findings may inform future studies assessing potential cardiometabolic harms associated with E-cigarette use.
Databáze: OpenAIRE
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