Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

Autor:	Hikaru Katayanagi, Naoki Sakai, Sota Hamada, Akihito Usui, Kota Aoki, Keita Kodama, Kentaro Nashimoto, Yoshiyuki Hosokai, Yuko Ichiyanagi
Rok vydání:	2022
Předmět:	Biomaterials ferrite magnetic nanoparticles theranostics relaxation Renewable Energy Sustainability and the Environment Materials Chemistry magnetic resonance imaging Energy Engineering and Power Technology
Zdroj:	ChemNanoMat. 8
ISSN:	2199-692X
DOI:	10.1002/cnma.202200014
Popis:	Co1-xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin-echo magnetic resonance imaging measurements for Co1-xMgxFe2O4 nanoparticles using a 0.3-T MRI system. The particles exhibited a significant T2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d589e019c20d3bd199799638a234c2 https://doi.org/10.1002/cnma.202200014 Zobrazit plný text záznamu Plný text