Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir
| Autor: | Peck-Sun Lin, William T. Hawkins, Cyrus Amir, Jeffrey Feden, Rupert Schmidt-Ullrich, Julie Farnsworth, Kristoffer Valerie |
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| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
Radiation-Sensitizing Agents viruses Mutant Blotting Western Genetic Vectors Acyclovir Apoptosis Antiviral Agents Thymidine Kinase Adenoviridae In vivo Transduction Genetic Glioma medicine Tumor Cells Cultured Animals Simplexvirus Molecular Biology Survival rate Dose-Response Relationship Drug Chemistry Brain Neoplasms Wild type Brain Dose-Response Relationship Radiation medicine.disease Molecular biology Combined Modality Therapy In vitro Rats Inbred F344 Rats Blot Survival Rate Dose–response relationship Mutation Cancer research Molecular Medicine Female Neoplasm Transplantation |
| Zdroj: | Cancer gene therapy. 8(1) |
| ISSN: | 0929-1903 |
| Popis: | We recently demonstrated in vitro that a mutant HSV-TK (mutant 75) expressed from an adenovirus (AdCMV-TK75) radiosensitized rat RT2 glioma cells significantly better than wild type HSV-TK (AdCMV-TK) in combination with acyclovir (ACV). To examine whether a similar improvement could also be observed in vivo, we tested these viruses in a syngeneic rat glioma tumor model (RT2/Fischer 344). First, we demonstrate that treatment with AdCMV-TK and ACV significantly radiosensitizes implanted gliomas and roughly doubles the mean survival time to 37 days, compared to 20 days for control animals implanted with Adbetagal-transduced cells (P |
| Databáze: | OpenAIRE |
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