Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres
| Autor: | Ivan Van Riet, Delphine Pranger, Anke De Geyndt, Florence Van Obbergh, Koen Theunissen, Pierre Zachee, Belgian Transplant Registry, Dominik Selleslag, Evelyne Willems, Marijke Vanspauwen, Yves Beguin, Hélène Poirel, Xavier Poiré, Nathalie Meuleman, Anke Verlinden, Virginie De Wilde, Aurélie Jaspers, Gilles Macq, Johan Maertens, Dries Deeren, Anne De Becker, Carlos Graux, Christine Schuermans, Tessa Kerre, Evelien Vaes |
|---|---|
| Přispěvatelé: | Belgian Transplant Registry, Belgian Haematological Soc, UCL - (MGD) Service d'hématologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Hematology, Faculty of Medicine and Pharmacy, Basic (bio-) Medical Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Databases Factual Quality Assurance Health Care medicine.medical_treatment Hematopoietic stem cell transplantation Transplantation Autologous Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Belgium Internal medicine medicine Humans Transplantation Homologous Survival rate Biology Adult patients business.industry hematology Physics Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Autologous hsct Middle Aged Sciences bio-médicales et agricoles medicine.disease Transplantation Survival Rate Leukemia medicine.anatomical_structure surgical procedures operative Homogeneous 030220 oncology & carcinogenesis Hematologic Neoplasms Female Human medicine business 030215 immunology transplantation |
| Zdroj: | Bone marrow transplantation, 54 (9 Bone marrow transplantation Bone marrow transplantation, Vol. 54, no. 9, p. 1434-1442 (2019) |
| ISSN: | 0268-3369 |
| Popis: | While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e. performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink