Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity
| Autor: | Michele E Barbour, James A. Holder, Peter F. Duckworth, Candice A. Bellis, Owen Addison, Angela H. Nobbs |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
food.ingredient
Materials science Compressive Strength BFS biaxial flexural strength Glass ionomer cement 02 engineering and technology Article Phosphates CS compressive strength Streptococcus mutans 03 medical and health sciences 0302 clinical medicine food Flexural strength HMP hexametaphosphate Caries Tensile Strength Ultimate tensile strength Flexural Strength Materials Testing medicine Agar General Materials Science Agar diffusion test Particle Size General Dentistry biology CHX chlorhexidine Antimicrobials Chlorhexidine Saliva Artificial 030206 dentistry 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial Drug Combinations Restorative materials Mechanics of Materials Glass Ionomer Cements Anti-Infective Agents Local DTS diametral tensile strength Bifidobacterium 0210 nano-technology GIC glass ionomer cement medicine.drug Nuclear chemistry |
| Zdroj: | Bellis, C A, Addison, O, Nobbs, A H, Duckworth, P F, Holder, J A & Barbour, M E 2018, ' Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity ', Dental Materials, vol. 34, no. 12, pp. 1717-1726 . https://doi.org/10.1016/j.dental.2018.09.003 Dental Materials Bellis, C A, Addison, O, Nobbs, A H, Duckworth, P F, Holder, J A & Barbour, M E 2018, ' Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity ', Dental Materials . https://doi.org/10.1016/j.dental.2018.09.003 |
| DOI: | 10.1016/j.dental.2018.09.003 |
| Popis: | Highlights • Milled, dry chlorhexidine hexametaphosphate (CHX-HMP) was incorporated into a GIC. • CHX release was dose-dependent and sustained for at least 660 days. • GICs could be recharged with CHX and CHX-HMP. • 1% CHX-HMP did not affect compressive, tensile or biaxial flexural strength. • CHX-HMP GICs inhibited growth of cariogenic microorganisms in an agar diffusion model. Objective Glass ionomer cements (GICs) are a versatile material, offering the opportunity for ion exchange with the oral environment. The aim of this study was to develop a GIC that delivers a controlled, rechargeable dose of chlorhexidine (CHX) over an extended period without compromising mechanical properties. Methods GICs were supplemented with finely milled particles of chlorhexidine hexametaphosphate (CHX-HMP). CHX release into artificial saliva was measured over 660 days, and recharge with CHX and CHX-HMP was investigated. Mechanical properties were investigated, and an agar diffusion test was carried out to assess antimicrobial properties using Streptococcus mutans and Scardovia wiggsiae. Results Dose-dependent CHX release was observed, and this was ongoing at 660 days. Compared with related studies of GICs containing CHX-HMP, the fine, dry particles resulted in fewer adverse effects on mechanical properties, including tensile, compressive and biaxial flexural strength, with 1% CHX-HMP GICs indistinguishable from control specimens. The GICs could be recharged with CHX using both a conventional CHX digluconate solution comparable to commercial mouthrinses, and a suspension of CHX-HMP of equivalent concentration. Recharging with CHX digluconate increased subsequent CHX release by 50% compared with no recharge, and recharging with CHX-HMP increased subsequent CHX release by 100% compared with no recharge. The GICs inhibited growth of St. mutans and Sc. wiggsiae in a simple agar diffusion model. Significance These materials, which provide sustained CHX release over clinically relevant timescales, may find application as a restorative material intended to inhibit secondary caries as well as in temporary restorations and fissure sealants. |
| Databáze: | OpenAIRE |
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