Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy

Autor: Bernard Poitevin, Mireille Dron-Gonzalvez, Laureline Nicolau, Isabelle Cabon-Boudard, Céline Palussière, Anca Mirela Chiriac, Denis Charpin, Anne Sarrat, Pascal Demoly, C. Agabriel, Yannick Chantran, M. Vivinus, Bernard Hofmann, A. Poisson, Geneviève Liautard, Joana Vitte, Serge Vivinus, Rihane Arif-Lusson, Jonas Lidholm, Soraya Mezouar, Sylvie Leroy, Davide-Paolo Caimmi, Christophe Soler, Lisa Giovannini-Chami, J. Östling, Bertrand Lovato, Tunde Sofalvi, F. Porri, Thierry Bourrier, V. Liabeuf, A. Ehrenberg, Isabella Annesi-Maesano, Agnès Aferiat-Derome, Marion Gouitaa, Nathalie Bonardel, Lorna Garnier, Jean-Luc Bourrain, Joëlle Birnbaum, B. Sterling, Stéphane Guez, P.A. Apoil, Ania Carsin, C. Klingebiel, Yann-Patrick Massabie-Bouchat, Jean-Louis Mege, Franck Boralevi
Přispěvatelé: Laboratoire Synlab Provence, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Thermo Fisher Scientific (Bremen) GmbH, Hôpital Saint-Joseph [Marseille], Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier d'Aix en Provence [Aix-en-Provence] (CHIAP ), Service d'immunologie et d'immunogénétique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital Archet 2 [Nice] (CHU), Service d'immunologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Université de Montpellier (UM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Bordeaux [Bordeaux], Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Médical de Mérignac, Centre Médical de Cenon, Hôpital Pasteur [Nice] (CHU), Hôpitaux Pédiatriques de Nice Lenval (CHU-Lenval), Centre Hospitalier Universitaire de Nice (CHU Nice), Assistance Publique - Hôpitaux de Marseille (APHM), Espace Médical Castellane, Centre Hospitalier de Carpentras, Centre Hospitalier de Martigues, Centre hospitalier de Bormes-les-Mimosas, Centre Hospitalier Saint Jean de Perpignan, Centre Hospitalier de Solliès-Pont, Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Société Française d'Allergologie, Sorbonne Université (SU), Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Institut Fédératif de Biologie (IFB) - Hôpital Purpan, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), COMBE, Isabelle
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Allergy
Basophil
peamaclein
MESH: Food Hypersensitivity / diagnosis
medicine.disease_cause
Immunoglobulin E
MESH: Cupressus / immunology
basophil
0302 clinical medicine
Allergen
MESH: Risk Factors
MESH: Child
Immunology and Allergy
MESH: Antigens
Plant / immunology
MESH: Food Hypersensitivity / immunology
Sensitization
Pru p 7
2. Zero hunger
MESH: Aged
0303 health sciences
MESH: Immunoglobulin E / immunology
MESH: Middle Aged
biology
immunological tests
MESH: Infant
3. Good health
medicine.anatomical_structure
MESH: Young Adult
MESH: Cross Reactions / immunology
MESH: Immunization
[SDV.IMM]Life Sciences [q-bio]/Immunology
IgE
Anaphylaxis
MESH: Basophils / metabolism
MESH: Basophils / immunology
[SDV.IMM] Life Sciences [q-bio]/Immunology
Immunology
MESH: Disease Susceptibility
03 medical and health sciences
Food allergy
MESH: Severity of Illness Index
medicine
anaphylaxis
MESH: Prevalence
030304 developmental biology
MESH: Adolescent
food allergy
MESH: Pollen / immunology
MESH: Humans
business.industry
MESH: Child
Preschool
MESH: Adult
MESH: Allergens / immunology
medicine.disease
MESH: Male
Basophil activation
allergens and epitopes
030228 respiratory system
MESH: Prunus persica / adverse effects
biology.protein
business
cypress pollinosis
MESH: Female
MESH: Food Hypersensitivity / epidemiology
Zdroj: Clinical and Experimental Allergy
Clinical and Experimental Allergy, 2019, 49 (4), pp.526-536. ⟨10.1111/cea.13345⟩
Clinical and Experimental Allergy, Wiley, 2019, 49 (4), pp.526-536. ⟨10.1111/cea.13345⟩
ISSN: 0954-7894
1365-2222
DOI: 10.1111/cea.13345⟩
Popis: BACKGROUND: Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen-related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin-regulated protein family occurs in areas with high Cupressaceae tree pollen exposure. OBJECTIVE: We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France. METHODS: Subjects with suspected peach allergy (n = 316) were included. Diagnostic work-up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform. RESULTS: Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach-induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests. CONCLUSION AND CLINICAL RELEVANCE: A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy.
Databáze: OpenAIRE
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