Serum DJ-1 level is positively associated with improvements in some aspects of metabolic syndrome in Japanese women through lifestyle intervention
| Autor: | Yukiko Minegishi, Manabu Musashi, Kiyoshi Moriya, Junko Suzuki, Atsuko Umezawa, Chizuru Kubo, Akira Makita, Naomi Furukawa, Mari Shimizu, Sato Murao, Iwao Ohkubo, Masayuki Saito, Mami Matsushita, Izumi Momose, Takuya Yamane, Atsuko Yamaguchi, Megumi Sakamoto, Aki Shirahata, Miyuki Kozuka, Ryoko Kobayashi, Hiroyoshi Ariga |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism Health Behavior Protein Deglycase DJ-1 Physiology Blood Pressure Disease Endocrinology Asian People Japan Internal medicine Diabetes mellitus medicine Diabetes Mellitus Body Size Humans Obesity Risk factor Exercise Life Style Aged Metabolic Syndrome Oncogene Proteins Nutrition and Dietetics business.industry Intracellular Signaling Peptides and Proteins Cancer Middle Aged medicine.disease Diet Blood pressure Adipose Tissue Female Metabolic syndrome business Body mass index Biomarkers |
| Zdroj: | Nutrition research (New York, N.Y.). 34(10) |
| ISSN: | 1879-0739 |
| Popis: | DJ-1 is a protein that is associated with Parkinson disease and cancer, and the reduction of DJ-1 function and expression is also thought to be a cause of diabetes and hypertension. However, little is known about the association between the plasma concentration of DJ-1 and risk of metabolic syndrome. We hypothesized that a lifestyle intervention would increase serum DJ-1 and that up-regulated DJ-1 functions will result in the prevention of metabolic syndrome. The objective of our study is to examine whether the level of serum DJ-1 is associated with the risk of metabolic syndrome. Therefore, to reveal the association between DJ-1 and metabolic syndrome, this study investigated lifestyle intervention in a control group (n = 37) and intervention group (n = 45). The results showed that body mass index, body fat ratio, waist-hip ratio, waist circumference, blood pressure, and plasma glucose level were improved in the intervention group, as compared with those in the control group. Furthermore, serum levels of DJ-1 were increased in the intervention group, when compared with those in the control group. These results suggest that serum DJ-1 is increased by lifestyle intervention and that increased serum DJ-1 prevents metabolic syndrome. Thus, the level of serum DJ-1 will become one of the indexes for the risk of metabolic syndrome. |
| Databáze: | OpenAIRE |
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