Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS)
| Autor: | Pia Johansson Heinsvig, Carolina Noble, Petur Weihe Dalsgaard, Marie Mardal |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Heinsvig, P J, Noble, C, Dalsgaard, P W & Mardal, M 2023, ' Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS) ', TrAC-Trends in Analytical Chemistry, vol. 162, 117023 . https://doi.org/10.1016/j.trac.2023.117023 Heinsvig, P J 2023, ' Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS) ', TrAC-Trends in Analytical Chemistry . |
| DOI: | 10.1016/j.trac.2023.117023 |
| Popis: | Liquid chromatography-high resolution mass spectrometry (LC-HRMS) has been widely used for screening small organic molecules in complex samples. Its selectivity and sensitivity allow for broad-scope screening of thousands of analytes. However, the complexity of the acquired data has complicated its implementation in high-throughput laboratories that analyze hundreds of samples per week and require that multiple users be able to analyze the data. Forensic laboratories have managed to harvest the merits of LC-HRMS technology using robust and often leveled data analysis(/acquisition) workflows, without spending a disproportionate amount of time evaluating inconclusive or false positive identifications. This critical review describes the full analytical process of LC-HRMS-based forensic drug screening, from sample preparation to data analysis and beyond. Interesting solutions are highlighted, and two emerging trends will be discussed: i) the use of free online tools to improve forensic drug screening, and ii) re-use of data to improve forensic services. Liquid chromatography-high resolution mass spectrometry (LC-HRMS) has been widely used for screening small organic molecules in complex samples. Its selectivity and sensitivity allow for broad-scope screening of thousands of analytes. However, the complexity of the acquired data has complicated its implementation in high-throughput laboratories that analyze hundreds of samples per week and require that multiple users be able to analyze the data. Forensic laboratories have managed to harvest the merits of LC-HRMS technology using robust and often leveled data analysis(/acquisition) workflows, without spending a disproportionate amount of time evaluating inconclusive or false positive identifications. This critical review describes the full analytical process of LC-HRMS-based forensic drug screening, from sample preparation to data analysis and beyond. Interesting solutions are highlighted, and two emerging trends will be discussed: i) the use of free online tools to improve forensic drug screening, and ii) re-use of data to improve forensic services. |
| Databáze: | OpenAIRE |
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