Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India
| Autor: | Aditya Nath Jha, Sheikh Nizamuddin, Jaydeep Badrukhiya, Abhishek Mishra, Sonika Pandey, Ajayi Ebenezer Idowu, Nitin Tupperwar, Kumarasamy Thangaraj, Pandarisamy Sundaravadivel, Umesh Kumar, Sakshi Singh, Rajan Kumar Jha, Sunil Kumar Tripathi, Isha Anerao, Anshuman Mishra, Akshay Sharma, Nipa Basak |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Genotype 030106 microbiology India Biology MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) lcsh:Infectious and parasitic diseases purl.org/becyt/ford/1 [https] Young Adult 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Genetic variation VISCERAL LEISHMANIASIS (VL) medicine Humans lcsh:RC109-216 Genetic Predisposition to Disease 030212 general & internal medicine Allele purl.org/becyt/ford/1.6 [https] Macrophage Migration-Inhibitory Factors Genetic Association Studies lcsh:Public aspects of medicine Haplotype Public Health Environmental and Occupational Health lcsh:RA1-1270 Leishmaniasis General Medicine LEISHMANIA MAJOR LEISHMANIA DONOVANI Middle Aged medicine.disease INDIAN POPULATION Infectious Diseases Visceral leishmaniasis Case-Control Studies Immunology Leishmaniasis Visceral Female Macrophage migration inhibitory factor GENETIC POLYMORPHISM |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Journal of Infection and Public Health, Vol 12, Iss 3, Pp 380-387 (2019) |
| Popis: | The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases. Role of MIF is well documented in leishmaniasis diseases, including Indian visceral leishmaniasis, where elevated level of serum MIF has been associated with VL phenotypes. However, there was no genetic study to correlate MIF variants in VL, therefore, we aimed to study the possible association of three reported MIF gene variants −794 CATT, −173G > C and non-coding RNA gene LOC284889 in Indian VL phenotype. Methods: Study subjects comprised of 214 VL patients along with ethnically and demographically matched 220 controls from VL endemic regions of Bihar state in India. Results: We found no significant difference between cases and controls in allelic, genotypic and haplotype frequency of the markers analysed [-794 CATT repeats (χ2 = 0.86; p = 0.35; OR = 0.85; 95% CI = 0.61?1.19); −173 G > C polymorphism (χ2 = 1.11; p = 0.29; OR = 0.83; 95% CI = 0.59?1.16); and LOC284889 (χ2 = 0.78; p = 0.37; OR = 0.86; 95% CI = 0.61?1.20)]. Conclusion: Since we did not find any significant differences between case and control groups, we conclude that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians. Fil: Mishra, Anshuman. Vinoba Bhave Research Institute; India. Centre For Cellular And Molecular Biology India; India Fil: Sundaravadivel, Pandarisamy. Centre For Cellular And Molecular Biology India; India Fil: Tripathi, Sunil Kumar. Centre For Cellular And Molecular Biology India; India Fil: Jha, Rajan Kumar. Centre For Cellular And Molecular Biology India; India Fil: Badrukhiya, Jaydeep. Centre For Cellular And Molecular Biology India; India Fil: Basak, Nipa. Academy Of Scientific And Innovative Research; India. Centre For Cellular And Molecular Biology India; India Fil: Anerao, Isha. Centre For Cellular And Molecular Biology India; India Fil: Sharma, A. Surja. Centre For Cellular And Molecular Biology India; India Fil: Ajayi, Ebenezer Idowu O. Centre For Cellular And Molecular Biology India; India. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Mishra, Abhishek. Institute Of Basic Sciences Agra; India Fil: Pandey, Sonika. Banaras Hindu University; India Fil: Kumar, Umesh. Centre For Cellular And Molecular Biology India; India Fil: Singh, Sakshi. Centre For Cellular And Molecular Biology India; India Fil: Nizamuddin, Sheikh. Centre For Cellular And Molecular Biology India; India Fil: Tupperwar, Nitin C.. Centre For Cellular And Molecular Biology India; India Fil: Jha, Aditya Nath. Sickle Cell Institute Chhattisgarh; India. Centre For Cellular And Molecular Biology India; India Fil: Thangaraj, Kumarasamy. Centre For Cellular And Molecular Biology India; India |
| Databáze: | OpenAIRE |
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