Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders
| Autor: | Sarah Colbert, Niamh Mullins, Grace Chan, Jacquelyn L. Meyers, Jessica Schulman, Samuel Kuperman, Dongbing Lai, John Nurnberger, Martin H. Plawecki, Chella Kamarajan, Andrey P. Anokhin, Kathleen K. Bucholz, Victor Hesselbrock, Howard J. Edenberg, John Kramer, Danielle M. Dick, Bernice Porjesz, Arpana Agrawal, Emma C. Johnson |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Complex Psychiatry. |
| ISSN: | 2673-298X 2673-3005 |
| DOI: | 10.1159/000529164 |
| Popis: | Suicidal thoughts and behaviors have partially distinct genetic etiologies. We used PRS-CS to create polygenic risk scores (PRS) from GWAS of non-suicidal self-injury, broad sense self-harm ideation, non-fatal suicide attempt, death by suicide, and depression. Using mixed-effect models, we estimated whether these PRS were associated with a range of suicidal thoughts and behaviors in the Collaborative Study on the Genetics of Alcoholism (N = 7,526). All PRS were significantly associated with suicidal ideation and suicide attempt (betas=0.08-0.44, FDR |
| Databáze: | OpenAIRE |
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