Sitagliptin plus pantoprazole can restore but not maintain insulin independence after clinical islet transplantation: results of a pilot study
| Autor: | Angela Koh, Peter A. Senior, Sharleen Imes, A. M. J. Shapiro, J. Yau, Parastoo Dinyari, Andrew J. Malcolm, P. Light |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Islets of Langerhans Transplantation Pilot Projects 030209 endocrinology & metabolism 030230 surgery Incretins Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Sitagliptin Phosphate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Diabetes Mellitus Internal Medicine medicine Clinical endpoint Humans Hypoglycemic Agents Insulin Pantoprazole Aged Glycated Hemoglobin Postoperative Care C-Peptide business.industry C-peptide Proton Pump Inhibitors Middle Aged medicine.disease Transplantation chemistry Sitagliptin Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Diabetic Medicine. 34:204-212 |
| ISSN: | 0742-3071 |
| Popis: | AIMS Resuming insulin use due to waning function is common after islet transplantation. Animal studies suggest that gastrointestinal hormones, including gastrin and incretins may increase β-cell mass. We tested the hypothesis that pantoprazole plus sitagliptin, would restore insulin independence in islet transplant recipients with early graft insufficiency and determined whether this would persist after a 3-month washout. METHODS Single-centre, uncontrolled, open label study of sitagliptin 100 mg daily plus pantoprazole 40 mg twice daily for 6 months. RESULTS After 6 months of treatment, two of eight participants (25%) achieved the primary endpoint, defined as HbA1C 0.5 nmol and no insulin use. There was a significant reduction in mean insulin dose, but no change in HbA1C or weight. There were no changes in the acute insulin response to arginine, the mixed meal tolerance test or blinded continuous glucose monitoring. After the washout, no participants met the primary endpoint and HbA1C increased from 45 ± 8 mmol/mol (6.3 ± 0.7%) to 51 ± 6 mmol/mol (6.8 ± 0.6%) (P < 0.05). Two participants had mild-moderate transient gastrointestinal side effects. There were no episodes of hypoglycaemia. CONCLUSIONS Sitagliptin plus pantoprazole is well tolerated and safe and may restore insulin independence in some islet transplant recipients with early graft insufficiency, but this was not sustained when treatment was withdrawn. A larger, controlled trial is required to confirm the effectiveness of this combination to achieve insulin independence and to confidently exclude any persistent benefit for graft function. (Clinical Trials Registry No.: NCT00768651). |
| Databáze: | OpenAIRE |
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