The role of the atrial electromechanical delay in predicting atrial fibrillation in beta-thalassemia major patients
| Autor: | Giovanni Cimmino, Vincenzo Russo, Anna Rago, Andrea Antonio Papa, Bruno Pannone, Carmine Ciardiello, Maria Carolina Mayer, Gerardo Nigro |
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| Přispěvatelé: | Rago, Anna, Russo, Vincenzo, Papa, Andrea Antonio, Ciardiello, Carmine, Pannone, Bruno, Mayer, Maria Carolina, Cimmino, Giovanni, Nigro, Gerardo |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cardiac function curve medicine.medical_specialty Population Comorbidity 030204 cardiovascular system & hematology BETA THALASSEMIA MAJOR Risk Assessment Sensitivity and Specificity Electrocardiography 03 medical and health sciences 0302 clinical medicine Tissue Doppler echocardiography Physiology (medical) Internal medicine Humans Medicine education Excitation Contraction Coupling P-wave dispersion education.field_of_study business.industry Incidence beta-Thalassemia Healthy subjects Reproducibility of Results Atrial fibrillation Beta-thalassemia major medicine.disease Both atria Causality Italy Echocardiography 030220 oncology & carcinogenesis Cardiology Female Cardiology and Cardiovascular Medicine business Atrial electromechanical delay Loop recorder |
| Popis: | Background Paroxysmal atrial tachyarrhythmias frequently occur in beta-thalassemia major (beta-TM) patients. The aim of the current study was to evaluate the atrial electromechanical delay (AEMD) in a large beta-TM population with normal cardiac function and its relationship to atrial fibrillation (AF) onset.Methods Eighty beta-TM patients ( 44 men, 36 women), with a mean age of 36.2 +/- 11.1 years, and 80 healthy subjects used as controls, matched for age and gender, were studied for the occurrence of AF during a 5-year follow-up, through 30-day external loop recorder (ELR) monitoring performed every 6 months. Intra-AEMD and inter-AEMD of both atria were measured through tissue Doppler echocardiography. P-wave dispersion (PD) was carefully measured using 12-lead electrocardiogram ( ECG).Results Compared to the healthy control group, the beta-TM patients showed a statistically significant increase in inter-AEMD, intra-left AEMD, maximum P-wave duration, and PD. Dividing the beta-TM group into two subgroups (patients with or without AF), the inter-AEMD, intra-left AEMD, maximum P-wave duration, and PD were significantly higher in the subgroup with AF compared to the subgroup without AF. There were significant good correlations of intra-left AEMD and inter-AEMD with PD. A cut-off value of 40.1 ms for intra-left AEMD had a sensitivity of 76.2% and a specificity of 97.5% in identifying beta-TM patients with AF risk. A cut-off value of 44.8 ms for inter-AEMD had a sensitivity of 81.2% and a specificity of 98.7% in identifying this category of patients.Conclusions Our results showed that the echocardiographic atrial electromechanical delay indices (intra-left and inter-AEMD) and the PD were significantly increased in beta-TM subjects with normal cardiac function. PD and AEMD represent non-invasive, inexpensive, useful, and simple parameters to assess the AF risk in beta-TM patients. |
| Databáze: | OpenAIRE |
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