Local tumor control after 106Ru brachytherapy of choroidal melanoma
| Autor: | Helen Mayles, Bertil Damato, R. Douglas Errington, Imran I. Patel, Ian R. Campbell |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Brachytherapy Optic disk Basal (phylogenetics) Clinical Protocols medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Treatment Failure Prospective cohort study Melanoma Aged Proportional Hazards Models Aged 80 and over Analysis of Variance Univariate analysis Radiation business.industry Plaque radiotherapy Choroid Neoplasms Incidence Middle Aged Confidence interval Surgery Radiation therapy Oncology Female Radiology Neoplasm Recurrence Local Ruthenium Radioisotopes business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 63:385-391 |
| ISSN: | 0360-3016 |
| Popis: | Purpose To report on local tumor control after 106 Ru brachytherapy for choroidal melanoma. Methods and Materials A total of 458 patients with choroidal melanoma were treated at a single institution between January 1993 and December 2001. The tumors had a median longest basal dimension of 10.6 mm and a median height of 3.2 mm. The brachytherapy was administered using a 15- or 20-mm plaque. For posterior tumors, the plaque was positioned eccentrically with its posterior edge aligned with the posterior tumor margin to reduce the radiation dose to the optic disk and fovea. A minimal scleral dose sufficient to cause visible choroidal atrophy provided a permanent ophthalmoscopic record of the distribution of choroidal irradiation. If radiotherapy to the posterior tumor was uncertain, adjunctive transpupillary thermotherapy was administered 6 months postoperatively. Results The actuarial rates of tumor recurrence were 1%, 2%, and 3% at 2, 5, and 7 years, respectively. Local tumor recurrence correlated with the longest basal tumor dimension (Cox univariate analysis, p = 0.02, risk ratio 1.41, 95% confidence interval 1.06–1.88). Seven of the nine eyes with recurrent tumor were salvaged with additional conservative therapy. Conclusion The low rate of local tumor recurrence suggests that ruthenium plaque radiotherapy is effective with good case selection and if special measures are taken to ensure that the plaque is positioned correctly. |
| Databáze: | OpenAIRE |
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