European Veterinary Renal Pathology Service: A Survey Over a 7-Year Period (2008-2015)

Autor: Davide Trez, Silvia Benali, J.J. van der Lugt, Eric Zini, R. Dalla Riva, C. Brovida, Valeria Martini, Luca Aresu, A.M. van Dongen, Rachel E. Cianciolo
Přispěvatelé: University of Zurich, Aresu, L
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Veterinary medicine
10253 Department of Small Animals
3400 General Veterinary
Biopsy
Standard Article
Kidney
0403 veterinary science
Glomerulonephritis
Surveys and Questionnaires
Diagnosis
Dog
Nephrology/Urology
Minimal change disease
Dog Diseases
Registries
Hypoalbuminemia
Microscopy
630 Agriculture
medicine.diagnostic_test
Not Otherwise Specified
04 agricultural and veterinary sciences
Standard Articles
Europe
medicine.anatomical_structure
Renal pathology
Veterinary (all)
Female
Kidney Diseases
Renal biopsy
040301 veterinary sciences
Nephropathy
03 medical and health sciences
Dogs
Electron microscopy
medicine
Animals
General Veterinary
business.industry
medicine.disease
Microscopy
Electron
030104 developmental biology
570 Life sciences
biology
SMALL ANIMAL
business
Zdroj: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
DOI: 10.1111/jvim.14796
Popis: Background The European Veterinary Renal Pathology Service (EVRPS) is the first Web-based registry for canine renal biopsy specimens in Europe. Hypothesis/Objectives The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS. Animals Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162). Methods Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune-complex-mediated glomerulonephritis (ICGN), non-immune-complex-mediated GN (non-ICGN), and renal lesions not otherwise specified (RL-NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables. Results Serum albumin concentration was lower in dogs with ICGN than in those with non-ICGN (P = 0.006) or RL-NOS (P = 0.000), and the urine protein-to-creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II. Conclusions and clinical importance Dogs with ICGN, in particular MPGN, had higher protein loss than those with non-ICGN or RL-NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results.
Databáze: OpenAIRE
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