Comparison of the acute vascular effects of frusemide and bumetanide
| Autor: | G D Johnston, D. P. Nicholls, GB Kondowe, MB Finch |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Diuresis Pharmacology Plasma renin activity chemistry.chemical_compound Furosemide Internal medicine Renin Renin–angiotensin system medicine Humans Pharmacology (medical) Diuretics Aldosterone Bumetanide business.industry Endocrinology medicine.anatomical_structure chemistry Regional Blood Flow Vascular resistance Blood Vessels Drug Evaluation Female Vascular Resistance Diuretic business Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 21:359-364 |
| ISSN: | 0306-5251 |
| Popis: | The acute peripheral vascular and diuretic effects of intravenous frusemide 10 mg and 20 mg were compared with those of bumetanide 250 micrograms and 500 micrograms in a group of 10 salt depleted volunteers. Significant reductions in forearm blood flow (FBF) were observed after frusemide 10 mg (-0.77 ml 100 ml-1 min-1 P less than 0.05) and 20 mg (-0.75 ml 100 ml-1 min-1 P less than 0.01 at 15 min). No changes were observed after bumetanide. The reductions in blood flow produced by frusemide were significantly different from those of bumetanide (P less than 0.05) at 15 min. Increases in venous capacitance (VC) and mean arterial blood pressure (MAP) were observed after frusemide but these differences were not statistically different from placebo or bumetanide. No increases were seen after bumetanide. Plasma aldosterone concentrations were unchanged after either drug but plasma renin activity (PRA) was increased after frusemide 10 mg (4.42 +/- 1.01----8.50 +/- 1.90 ng A I ml-1 h-1 P less than 0.01) and 20 mg (4.01 +/- 0.72----7.81 +/- 2.27 ng A I ml-1 h-1 P less than 0.05). No increases were observed after bumetanide and significant differences between bumetanide and frusemide were observed (P less than 0.01). This study demonstrates that the acute peripheral arterial effects of frusemide are not observed after comparable diuretic doses of bumetanide. The differences appear to be related to the ability of the drugs to stimulate acute renin release from the kidney. |
| Databáze: | OpenAIRE |
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