Adenovirus Vector-Induced Immune Responses in Nonhuman Primates: Responses to Prime Boost Regimens
| Autor: | Nia, Tatsis, Marcio O, Lasaro, Shih-Wen, Lin, Larissa H, Haut, Zhi Q, Xiang, Dongming, Zhou, Lauren, Dimenna, Hua, Li, Ang, Bian, Sarah, Abdulla, Yan, Li, Wynetta, Giles-Davis, Jessica, Engram, Sarah J, Ratcliffe, Guido, Silvestri, Hildegund C, Ertl, Michael R, Betts |
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| Rok vydání: | 2009 |
| Předmět: |
Pan troglodytes
T-Lymphocytes Genetic Vectors Human Immunodeficiency Virus Proteins Immunology Immunization Secondary Heterologous Enzyme-Linked Immunosorbent Assay Antibodies Viral Lymphocyte Activation medicine.disease_cause Polymerase Chain Reaction Article Adenoviridae Viral vector Interferon-gamma Immune system medicine Animals Immunology and Allergy Vector (molecular biology) AIDS Vaccines biology Macaca mulatta Virology Vaccination Immunization biology.protein Interleukin-2 Antibody |
| Zdroj: | The Journal of Immunology. 182:6587-6599 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.0900317 |
| Popis: | In the phase IIb STEP trial an HIV-1 vaccine based on adenovirus (Ad) vectors of the human serotype 5 (AdHu5) not only failed to induce protection but also increased susceptibility to HIV-1 infection in individuals with preexisting neutralizing Abs against AdHu5. The mechanisms underlying the increased HIV-1 acquisition rates have not yet been elucidated. Furthermore, it remains unclear if the lack of the vaccine’s efficacy reflects a failure of the concept of T cell-mediated protection against HIV-1 or a product failure of the vaccine. Here, we compared two vaccine regimens based on sequential use of AdHu5 vectors or two different chimpanzee-derived Ad vectors in rhesus macaques that were AdHu5 seropositive or seronegative at the onset of vaccination. Our results show that heterologous booster immunizations with the chimpanzee-derived Ad vectors induced higher T and B cell responses than did repeated immunizations with the AdHu5 vector, especially in AdHu5-preexposed macaques. |
| Databáze: | OpenAIRE |
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