Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
| Autor: | Egardo Caamaño, Carmen Romero, Macarena Lépez, Jenny L. Fiedler, Verónica Araya |
|---|---|
| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Saliva Hydrocortisone business.industry Case-control study General Medicine medicine.disease Gastroenterology Cushing syndrome Endocrinology Internal medicine medicine Circadian rhythm Young adult business Salivary cortisol Depression (differential diagnoses) medicine.drug |
| Zdroj: | Revista médica de Chile v.138 n.2 2010 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | BACKGROUND: Salivary cortisol measurement is recommended as a screening mea-sure when a Cushing Syndrome is suspected. The proposed cut-off point for a probably diagnosis is 0.16 ug/dL. AIM: To determine salivary cortisol concentrations during the day inpatients with and without Cushing syndrome and with depression. MATERIAL AND METHODS: Salivary cortisol was measured by competitive enzyme immuno assay (EIA), in samples obtained at 8:00,15:00 and 23:00 h in 78 patients without Cushing syndrome, aged 40 +/- 15 years (28 males), 30 patients with depression aged 40 +/- 12 years (nine males) and four females with Cushing syndrome aged 42 +/- 17 years. RESULTS: Salivary cortisol was higher among patients with Cushing syndrome than the rest of patients. A salivary cortisol over the cut-off value of O.16 ug/dL was found in 42% of subjects without Cushing syndrome and in 33% of patients with depression. Median values among patients without Cushing syndrome, depression and with Cushing syndrome were 0.21 (range < 0.1-1.42), 0.2 (range 0,12-0.9) and 0.58 (range 0.37-1.1) ug/dL, respectively CONCLUSIONS: Salivary cortisol measured by EIA method was higher among patients with Cushing syndrome but there was a great overlap with values obtained in subjects without the syndrome. |
| Databáze: | OpenAIRE |
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