Attenuated spread of X-inactivation in an X;autosome translocation
| Autor: | Neil Brockdorff, Nobuo Takagi, Tatyana B. Nesterova, Bilyana C. Popova, Takashi Tada |
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| Rok vydání: | 2006 |
| Předmět: |
RNA
Untranslated X Chromosome Chromosomal translocation Biology Translocation Genetic X-inactivation Cell Line Histones Mice X Chromosome Inactivation Animals Humans Gene Silencing Skewed X-inactivation In Situ Hybridization Fluorescence X chromosome Multidisciplinary Autosome Lysine RNA Biological Sciences Non-coding RNA Chromosomes Mammalian Molecular biology Long Interspersed Nucleotide Elements Female RNA Long Noncoding XIST |
| Zdroj: | Proceedings of the National Academy of Sciences. 103:7706-7711 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0602021103 |
| Popis: | X inactivation in female mammals involves transcriptional silencing of an entire chromosome in response to a cis-acting noncoding RNA, the X inactive-specific transcript ( Xist ). Xist can also inactivate autosomal sequences, for example, in X;autosome translocations; but here, silencing appears to be relatively inefficient. This variation has been attributed to either attenuated spreading of Xist RNA at the onset of X inactivation or inefficient maintenance of autosomal silencing. Evidence to date has favored the latter. Here, we demonstrate attenuated spreading of Xist RNA at the onset of X inactivation in the T(X;4)37H X;autosome translocation. Our findings provide direct evidence that underlying chromosome/chromatin features can disrupt spreading of the primary inactivating signal. |
| Databáze: | OpenAIRE |
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