Effectiveness of Liposomal Bupivacaine Compared With Standard-of-Care Measures in Pediatric Cardiothoracic Surgery: A Retrospective Cohort Study
| Autor: | Mary Helen Tran, Jennifer H. Lin, Christopher F. Tirotta |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Standard of care Opioid consumption medicine.medical_treatment Psychological intervention 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Medicine Humans Anesthetics Local Child Retrospective Studies Pain Postoperative business.industry Postsurgical pain Retrospective cohort study Liposomal Bupivacaine Bupivacaine Analgesics Opioid Anesthesiology and Pain Medicine Cardiothoracic surgery Emergency medicine Video-assisted thoracoscopic surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cardiothoracic and vascular anesthesia. 35(12) |
| ISSN: | 1532-8422 |
| Popis: | Effective postsurgical pain management is important for pediatric patients to improve outcomes while reducing resource use and waste. The authors examined opioid consumption and economic outcomes associated with liposomal bupivacaine (LB) or non-LB analgesia use in pediatric patients undergoing cardiothoracic surgery.The authors retrospectively analyzed Premier Healthcare Database records.The data extracted from the database included patient records from hospitals across the United States in both rural and urban locations.The records included data from patients aged 12-to-18 years.The records belonged to patients undergoing video-assisted thoracoscopic procedures (VATS) who received LB or non-LB analgesia after surgery.Outcomes included in-hospital postsurgical opioid consumption in morphine milligram equivalents (MMEs), hospital length of stay (LOS), and total hospital costs; the LB and non-LB cohorts were compared using a generalized linear model with inverse probability of treatment weighting to balance the cohorts. For VATS procedures, pediatric patients receiving LB had significant reductions in in-hospital opioid consumption (632 v 991 MMEs; p0.0001), shorter LOS (5.1 v 5.6 days; p = 0.0023), and lower total hospital costs ($18,084 v $21,962; p0.0001) compared with those receiving non-LB analgesia.These results support use of LB in multimodal analgesia regimens for managing pain in pediatric patients after cardiothoracic surgery. |
| Databáze: | OpenAIRE |
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