Effect of Roux-en-Y gastric surgery on ciprofloxacin pharmacokinetics: an obvious effect?
| Autor: | María del Rosario Salas-Butrón, Fernando Bandrés, Luis Miguel Chicharro, Antonio José Torres García, Ana Terleira, Antonio Portolés, Emilio Vargas, Andrés Sánchez Pernaute, Ana Belén Rivas, Carmen Moreno Lopera, Amanda López-Picado, Miguel Angel Rubio Herrera |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Gastric Bypass Cmax 030226 pharmacology & pharmacy Young Adult 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Ciprofloxacin Weight loss Weight Loss medicine Humans Pharmacology (medical) Obesity Prospective Studies 030212 general & internal medicine Pharmacology business.industry Body Weight General Medicine Venous blood Middle Aged Roux-en-Y anastomosis Anti-Bacterial Agents Surgery Case-Control Studies Mann–Whitney U test Analysis of variance medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 75:647-654 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS). Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18–60 years old were included. The assessment was performed once in control patients and three times in case patients (before surgery and 1 and 6 months after surgery). In each visit, the subjects received a single oral dose of ciprofloxacin 500 mg. Venous blood samples were obtained at baseline and 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 8 and 14 h after ciprofloxacin intake. Pre- and post-surgery variables were compared using paired ANOVA or the Wilcoxon tests and control vs cases using ANOVA or Mann Whitney. Given the post-surgery change in body weight, the parameters were corrected by dose (mg)/body weight (kg). The analysis was performed using SPSS. Ciprofloxacin Cmax was significantly reduced 1 month after surgery (1840.9 ± 485.2 vs 1589.6 ± 321.8 ng/ml; p = 0.032) but not 6 months after. Cmax on the sixth month was lower than Cmax in control group (2160.4 ± 408.6 vs 1589.6 ± 321.8 ng/ml; p |
| Databáze: | OpenAIRE |
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