Celecoxib vs prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind clinical trial
| Autor: | Soodeh Razeghi Jahromi, Seyed Mohammad Hassan Paknejad, Mansoureh Togha, Foad Taghdiri |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Randomization Visual Analog Scale Visual analogue scale Anti-Inflammatory Agents Statistics Nonparametric Chronic Migraine Double-Blind Method Prednisone medicine Headache Disorders Secondary Humans In patient Prospective Studies Sulfonamides Cyclooxygenase 2 Inhibitors Dose-Response Relationship Drug business.industry Middle Aged Clinical trial Neurology WITHDRAWAL HEADACHE Celecoxib Anesthesia Pyrazoles Female Neurology (clinical) business medicine.drug |
| Zdroj: | Headache. 55(1) |
| ISSN: | 1526-4610 |
| Popis: | Objective To compare the efficacy of celecoxib for treatment of withdrawal headache vs prednisone in patients with medication overuse headache (MOH). Methods In this prospective, double-blind, parallel-group clinical trial, 97 consecutive subjects with MOH were randomized (simple randomization using computer-generated numbers) for treatment with either 400 mg/day celecoxib (for the first 5 days then decreased at a rate of 100 mg every 5 days) or prednisone 75 mg/day orally (for the first 5 days then tapered off every 5 days). Subjects who met the International Headache Society criteria for MOH were included in the trial. The change in headache days and intake of rescue medication were considered as primary outcomes while the change in headache severity defined as a secondary outcome. Results Patients treated with celecoxib experienced lower headache intensity during the first 3 weeks after withdrawal (after 3 weeks, the median of visual analog scale was 3 for patients in celecoxib group vs 4.5 for prednisone group [P |
| Databáze: | OpenAIRE |
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