Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial
| Autor: | Vanessa Campos, Philippe Schneiter, Camille Despland, Roland Kreis, Luc Tappy, Vaclav Brandejsky, Christoph Hans Boesch |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male cardiovascular risk factors Fatty Acids Nonesterified 030204 cardiovascular system & hematology Body Mass Index fructose chemistry.chemical_compound 0302 clinical medicine Insulin Ingestion Medicine Meals Nutrition and Dietetics digestive oral and skin physiology Postprandial Period Treatment Outcome Postprandial Female Nutritive Sweeteners lcsh:Nutrition. Foods and food supply intrahepatocellular lipid concentration Adult medicine.medical_specialty hypertriglyceridemia lcsh:TX341-641 030209 endocrinology & metabolism Glucagon Article Young Adult Blood Glucose/metabolism Diet Fatty Acids Nonesterified/blood Fatty Liver/blood Glucagon/blood Humans Insulin/blood Lactic Acid/blood Nutritive Sweeteners/administration & dosage Nutritive Sweeteners/adverse effects Obesity/blood Overweight/blood Sweetening Agents/administration & dosage Sweetening Agents/adverse effects Triglycerides/blood Uric Acid/blood 03 medical and health sciences NEFA Internal medicine Lactic Acid Obesity Triglycerides Triglyceride business.industry Hypertriglyceridemia Overweight medicine.disease Uric Acid Fatty Liver Endocrinology chemistry Sweetening Agents Uric acid Steatosis business Food Science |
| Zdroj: | Campos, Vanessa; Despland, Camille; Brandejsky, Vaclav; Kreis, Roland; Schneiter, Philippe; Boesch, Christoph Hans; Tappy, Luc (2017). Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial. Nutrients, 9(3) Molecular Diversity Preservation International MDPI 10.3390/nu9030202 Nutrients, vol. 9, no. 3, pp. E202 Nutrients, Vol 9, Iss 3, p 202 (2017) Nutrients Nutrients; Volume 9; Issue 3; Pages: 202 |
| DOI: | 10.3390/nu9030202 |
| Popis: | OBJECTIVE Addition of fructose to the diet of normal weight and overweight subjects can increase postprandial plasma triglyceride and uric acid concentration. We, therefore, assessed whether replacing sugar-sweetened beverages (SSB) with artificially-sweetened beverages (ASB) in the diet of overweight and obese subjects would decrease these parameters. METHODS Twenty-six participants of the REDUCS study, which assessed the effects of replacing SSB by ASB over 12 weeks on intra-hepatocellular lipid concentration, were included in this sub-analysis. All were studied after a four-week run-in period during which they consumed their usual diet and SSBs, and after a 12-week intervention in which they were randomly assigned to replace their SSBs with ASBs (ASB arm) or to continue their usual diet and SSBs (control arm, CTRL). At the end of run-in (week 4) and again at the end of intervention (week 16), they took part in an 8.5 h metabolic investigation during which their plasma glucose, insulin, glucagon, lactate, triglyceride (TG), non-esterified fatty acids (NEFA), and uric acid concentrations were measured over a 30 min fasting period (-30-0 min), then every 2 h over 480 min. with ingestion of standard breakfast at time 0 min and a standard lunch at time 240 min. Breakfast and lunch were consumed together with a 3.3 dL SSB at week 4 and with either an ASB (ASB arm) or a SSB (CTRL arm) at week 16. After analyzing the whole group, a secondary analysis was performed on 14 subjects with hepatic steatosis (seven randomized to ASB, seven to CTRL) and 12 subjects without hepatic steatosis (six randomized to ASB and six to CTRL). RESULTS Ingestion of meals increased plasma glucose, insulin, glucagon, lactate, and TG concentrations and decreased NEFA concentrations, but with no significant difference of integrated postprandial responses between week 4 and week 16 in both ASB and CTRL, except for a slightly decreased glucagon response in ASB. There was, however, no significant postprandial increase in uric acid concentration in both arms. In the secondary analysis, replacing SSBs with ASBs did not significantly change postprandial TG and uric acid concentrations irrespective of the presence or not of hepatic steatosis, Conclusions: In overweight, high SSB consumers, replacing SSBs with ASBs during 12 weeks did not significantly alter post-prandial TG and uric acid concentration, in spite of the lower energy and fructose content of the meals. These effects were globally the same in subjects without and with hepatic steatosis. |
| Databáze: | OpenAIRE |
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