A comprehensive comparative review of adenosine diphosphate receptor antagonists
| Autor: | Eric Balmir, Fabienne Vastey, Jonathan Rapp, Erin Y Oh, Teena Abraham, Nasser Saad |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Acute coronary syndrome
Ticagrelor Prasugrel Adenosine Ticlopidine medicine.drug_class medicine.medical_treatment Thiophenes Pharmacology Bioinformatics Piperazines medicine Humans Pharmacology (medical) Drug Interactions Acute Coronary Syndrome Aspirin Prasugrel Hydrochloride business.industry Percutaneous coronary intervention General Medicine medicine.disease Receptor antagonist Clopidogrel Treatment Outcome Purinergic P2Y Receptor Antagonists business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Expert opinion on pharmacotherapy. 13(2) |
| ISSN: | 1744-7666 |
| Popis: | Thrombosis risk necessitates dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) receptor antagonist, in patients who have acute coronary syndrome. Current guidelines emphasize the critical role of dual antiplatelet therapy in both medical management and invasive strategy, especially in patients undergoing percutaneous coronary intervention. With the availability of multiple ADP-receptor antagonists, it is crucial to select the most appropriate agent for each patient.The pertinent trials were identified through a MEDLINE search, in addition to a manual search from the articles retrieved. This review examines the differences between clopidogrel, prasugrel and ticagrelor in terms of their pharmacological/pharmacokinetic properties, clinical efficacy, drug interactions and safety parameters.Prasugrel and ticagrelor exhibit greater platelet inhibition and superior efficacy compared with clopidogrel, at the expense of higher bleeding risk. Prasugrel and ticagrelor should be preferred over clopidogrel in patients who are at a high risk of thrombotic events with low risk of bleeding. Additionally, these two agents may offer advantage over clopidogrel in those patients who might have risk for drug resistance due to CYP2C19 polymorphism. In selecting the ideal agent for patients, clinicians should tailor the antiplatelet regimen by considering individual risk factors and medication characteristics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|