The role of lipid peroxidation in individuals with autism spectrum disorders
| Autor: | Ryoichi Shiroki, Kunio Yui, George Imataka, Hitomi Sasaki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurology Adolescent Docosahexaenoic Acids Autism Spectrum Disorder Biochemistry Lipid peroxidation 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine Malondialdehyde medicine Humans Child Arachidonic Acid business.industry medicine.disease Eicosapentaenoic acid Lipoproteins LDL 030104 developmental biology Endocrinology chemistry Eicosapentaenoic Acid Autism spectrum disorder Docosahexaenoic acid Child Preschool Autism lipids (amino acids peptides and proteins) Arachidonic acid Female Neurology (clinical) Lipid Peroxidation business 030217 neurology & neurosurgery Lipoprotein |
| Zdroj: | Metabolic brain disease. 35(7) |
| ISSN: | 1573-7365 |
| Popis: | The role of malondialdehyde-modified low-density lipoprotein (MDA-LDL), an oxidized LDL, in the pathophysiology of autism spectrum disorder (ASD) is unclear. We studied association between MDA-LDL and behavioral symptoms in 11 individuals with ASD and 7 age -matched normal controls. Behavioral symptoms were assessed using the Aberrant Behavior Checklists (ABC). Because small sample size in this study, three measures were conducted: first, employment of adaptive Lasso for enhancing the accuracy of prediction and interpretability; second, calculation of coefficient of variation for an appropriate selection of plasma variables; and third, selection of good candidates of plasma variables. Plasma levels of MDA-LDL, eicosapentaenoic acid, docosahexaenoic acid (DHA) and DHA/arachidonic acid ratios were significantly higher, while plasma superoxide dismutase (SOD) levels were significantly lower in the ASD group than in the control group. The total ABC scores were significantly higher in the ASD group than in the control group. Multiple linear regression analysis and the adaptive Lasso revealed association of increased plasma DHA levels with the ABC total scores and increased plasma MDA-LDL levels. Such association between DHA and plasma MDA-LDL levels may contribute to behavior in individuals with ASD. |
| Databáze: | OpenAIRE |
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