Helicobacter pylori susceptibility to fosfomycin, rifampin, and 5 usual antibiotics for H. pylori eradication
| Autor: | Naiden Kandilarov, Ivailo Evstatiev, Galina Gergova, Emilia Panteleeva, Ivan Mitov, Lubomir Davidkov, Lyudmila Boyanova |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Adult Male Adolescent medicine.drug_class Antibiotics Microbial Sensitivity Tests Fosfomycin Microbiology Levofloxacin Clarithromycin Drug Resistance Bacterial polycyclic compounds medicine Humans Child Aged biology Helicobacter pylori business.industry General Medicine biochemical phenomena metabolism and nutrition Middle Aged biology.organism_classification Anti-Bacterial Agents Multiple drug resistance Metronidazole Infectious Diseases Female Rifampin business Rifampicin medicine.drug |
| Zdroj: | Diagnostic microbiology and infectious disease. 79(3) |
| ISSN: | 1879-0070 |
| Popis: | The aim of the study was to assess Helicobacter pylori resistance to fosfomycin, rifampin, and 5 other antibiotics. Susceptibility of 50 consecutive H. pylori strains was tested by E test and breakpoint susceptibility testing method. Overall and primary resistance rates were amoxicillin 2.0 and 0%, metronidazole 34.0 and 31.2%, tetracycline 2.0 and 2.1%, levofloxacin 18.0 and 16.7%, rifampin 12.0 and 10.4%, and fosfomycin 8.3 and 6.5%, respectively. Clarithromycin resistance was >20.0% in all patients (22.0%) and in untreated subjects (20.8%). Rifampin resistance was higher than those usually reported. Quinolone resistance rose from 2005-2007 (8.7%) to 2012-2013 (18.0%). High double/multidrug resistance rates (overall 22.0% and 20.0% in untreated adults), including a 5-fold resistance, were found. In conclusion, fosfomycin and rifampin resistance rates were much lower than that of metronidazole and slightly lower than those of clarithromycin and levofloxacin. MICs90 of both fosfomycin and rifampin were lower than those of clarithromycin and metronidazole. Thus, in countries of high/increasing H. pylori resistance and multidrug resistance, both rifamycins and fosfomycin could be helpful in rescue regimens. |
| Databáze: | OpenAIRE |
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