New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025
Autor: | Xuewei Ye, Zhizhen Zhang, Wenxiu Xin, Siran Yu, Xiao-Yuan Lian |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Spectrometry
Mass Electrospray Ionization Staphylococcus aureus Magnetic Resonance Spectroscopy Pharmaceutical Science Anthraquinones Antineoplastic Agents Microbial Sensitivity Tests Polyenes antibacterial and antitumor activities Streptomyces Article Inhibitory Concentration 50 fradic acids A and B Minimum inhibitory concentration chemistry.chemical_compound Cell Line Tumor Drug Discovery Animals Humans marine Streptomyces fradiae lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) biology Cell growth Cell Cycle Checkpoints Glioma Cell cycle Streptomyces fradiae biology.organism_classification Antimicrobial Polyene Anti-Bacterial Agents Rats lcsh:Biology (General) Biochemistry chemistry Cell culture Colonic Neoplasms fradimycins A and B |
Zdroj: | Marine Drugs; Volume 10; Issue 11; Pages: 2388-2402 Marine Drugs, Vol 10, Iss 11, Pp 2388-2402 (2012) Marine Drugs |
ISSN: | 1660-3397 |
DOI: | 10.3390/md10112388 |
Popis: | Capoamycin-type antibiotics (2–5) and polyene acids (6, 7) were isolated from marine Streptomyces fradiae strain PTZ0025. Their structures were established by extensive nuclear magnetic resonance (NMR) and high resolution electron spray ionization mass spectroscopy (HRESIMS) analyses and chemical degradation. Compounds 3, 4, 6, 7 were found to be new and named as fradimycins A (3) and B (4), and fradic acids A (6) and B (7). Compounds 3–5 showed in vitro antimicrobial activity against Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 2.0 to 6.0 μg/mL. Interestingly, Compounds 3–5 also significantly inhibited cell growth of colon cancer and glioma with IC50 values ranging from 0.13 to 6.46 μM. Fradimycin B (4), the most active compound, was further determined to arrest cell cycle and induce apoptosis in tumor cells. The results indicated that fradimycin B (4) arrested the cell cycle at the G0/G1 phase and induced apoptosis and necrosis in colon cancer and glioma cells. Taken together, the results demonstrated that the marine natural products 3–5, particularly fradimycin B (4), possessed potent antimicrobial and antitumor activities. |
Databáze: | OpenAIRE |
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