Insulinogenic index and early phase insulin secretion predict increased risk of worsening glucose tolerance and of cystic fibrosis-related diabetes

Autor:	Kathryn J. Potter, Valérie Boudreau, Anne Bonhoure, François Tremblay, Annick Lavoie, Maité Carricart, Peter A. Senior, Rémi Rabasa-Lhoret
Rok vydání:	2022
Předmět:	Pulmonary and Respiratory Medicine Pediatrics Perinatology and Child Health
Zdroj:	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
ISSN:	1873-5010
Popis:	Measures of stimulated insulin secretion are emerging as important predictors of diabetes mellitus in at-risk populations. We analyzed the utility of clinical estimates of insulin secretion in a prospective cohort at risk for cystic fibrosis-related diabetes (CFRD).We divided the profiles of 189 people with CF (pwCF) followed longitudinally in the Montreal CF cohort (mean follow up 6.6 ± 1.2 years) according to quartiles of the insulinogenic index (IGI; (IAt baseline, IGI and AUCIGI is easily measured in a clinical setting and needs to be validated in prospective studies as a potential tool to improve risk stratification in CFRD with direct relevance to pathogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b67a649105c11a362f63d12ef93510 https://pubmed.ncbi.nlm.nih.gov/36028423 Zobrazit plný text záznamu Full Text from ScienceDirect