The Past, Present, and Future of Preimplantation Genetic Testing
| Autor: | Anthony N. Imudia, Shayne Plosker |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics 030219 obstetrics & reproductive medicine medicine.diagnostic_test Biochemistry (medical) Clinical Biochemistry Genetic Diseases Inborn Aneuploidy Embryo History 20th Century Biology medicine.disease History 21st Century 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Pregnancy Chromosomal structural abnormalities medicine Humans Savior sibling Female Preimplantation Diagnosis Genetic testing |
| Zdroj: | Clinics in Laboratory Medicine. 36:385-399 |
| ISSN: | 0272-2712 |
| DOI: | 10.1016/j.cll.2016.01.012 |
| Popis: | Preimplantation genetic testing (PGT) of oocytes and embryos is the earliest form of prenatal testing. PGT requires in vitro fertilization for embryo creation. In the past 25 years, the use of PGT has increased dramatically. The indications of PGT include identification of embryos harboring single-gene disorders, chromosomal structural abnormalities, chromosomal numeric abnormalities, and mitochondrial disorders; gender selection; and identifying unaffected, HLA-matched embryos to permit the creation of a savior sibling. PGT is not without risks, limitations, or ethical controversies. This review discusses the techniques and clinical applications of different forms of PGT and the debate surrounding its associated uncertainty and expanded use. |
| Databáze: | OpenAIRE |
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