Impact of variceal eradication on rebleeding and prognosis in cirrhotic patients undergoing secondary prophylaxis
| Autor: | Yanna Liu, Xiaolong Qi, Jin Tao, Wu Bin, Jinni Luo, Yunwei Guo, Xing Wang, Jian-Zhong Li, Xiao-Ying Wu, Xiaoliang Chen, Xiu-Qing Wei, Feng-ping Zheng, Hong Tian, Chuan Liu, Zhuo-Fu Wen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Variceal bleeding medicine.diagnostic_test business.industry Incidence (epidemiology) Secondary prophylaxis General Medicine Logistic regression Endoscopy Surgery 03 medical and health sciences 0302 clinical medicine Interquartile range 030220 oncology & carcinogenesis Medicine Original Article 030211 gastroenterology & hepatology Cumulative incidence Prospective cohort study business |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5839 |
| Popis: | BACKGROUND: Endoscopic therapy has been widely applied to prevent variceal rebleeding, but data addressing the effect of endoscopic variceal eradication (VE) are lacking. We aimed to clarify the clinical impact of VE and reveal the long-term incidence and mortality of gastrointestinal rebleeding. METHODS: This prospective study included 228 cirrhotic patients who underwent secondary prophylaxis for variceal bleeding and achieved VE through a systematic procedure we proposed as endoscopic sequential therapy (EST). Rebleeding rates before and after VE were compared and cumulative incidence of rebleeding and mortality were calculated using the Kaplan-Meier method. A logistic regression model and P for trend were used to investigate the optimal time limit for VE. RESULTS: During a median (interquartile range) follow-up duration of 33.0 (23.0–48.75) months, rebleeding was identified in 28 patients (12.3%) after VE and in 27 patients (11.8%) during endoscopic sessions. The cumulative incidence of rebleeding before and after VE was 8.4% and 1.8% at 6 months, and 14.9% and 4.0% at 1 year respectively (P12 months (P for trend |
| Databáze: | OpenAIRE |
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