Genetic architecture and candidate genes detected for chicken internal organ weight with a 600 K single nucleotide polymorphism array
| Autor: | Meng Ma, Guo Jun, Manman Shen, Qu Liang, Hu Yuping, Dou Taocun, Jian Lu, Wang Kehua, Li Yongfeng, Wang Xingguo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Candidate gene
Linkage disequilibrium Haploview Genome-wide Association Study lcsh:Animal biochemistry Single-nucleotide polymorphism Genome-wide association study Quantitative trait locus Biology Article Fitness Trait Quantitative Trait lcsh:QP501-801 lcsh:SF1-1100 Genetics 0402 animal and dairy science 04 agricultural and veterinary sciences Heritability Animal Breeding and Genetics 040201 dairy & animal science Chicken Condensin I complex Internal Organ Animal Science and Zoology lcsh:Animal culture Food Science |
| Zdroj: | Asian-Australasian Journal of Animal Sciences, Vol 32, Iss 3, Pp 341-349 (2019) Asian-Australasian Journal of Animal Sciences |
| ISSN: | 1976-5517 1011-2367 |
| Popis: | Objective Internal organs indirectly affect economic performance and well-being of animals. Study of internal organs during later layer period will allow full utilization of layer hens. Hence, we conducted a genome-wide association study (GWAS) to identify potential quantitative trait loci or genes that potentially contribute to internal organ weight. Methods A total of 1,512 chickens originating from White Leghorn and Dongxiang Blue-Shelled chickens were genotyped using high-density Affymetrix 600 K single nucleotide polymorphism (SNP) array. We conducted a GWAS, linkage disequilibrium analysis, and heritability estimated based on SNP information by using GEMMA, Haploview and GCTA software. Results Our results displayed that internal organ weights show moderate to high (0.283 to 0.640) heritability. Variance partitioned across chromosomes and chromosome lengths had a linear relationship for liver weight and gizzard weight (R2 = 0.493, 0.753). A total of 23 highly significant SNPs that associated with all internal organ weights were mainly located on Gallus gallus autosome (GGA) 1 and GGA4. Six SNPs on GGA2 affected heart weight. After the final analysis, five top SNPs were in or near genes 5-Hydroxytryptamine receptor 2A, general transcription factor IIF polypeptide 2, WD repeat and FYVE domain containing 2, non-SMC condensin I complex subunit G, and sonic hedgehog, which were considered as candidate genes having a pervasive role in internal organ weights. Conclusion Our findings provide an understanding of the underlying genetic architecture of internal organs and are beneficial in the selection of chickens. |
| Databáze: | OpenAIRE |
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