Endometrial microstructure after long-term use of a 91-day extended-cycle oral contraceptive regimen
| Autor: | Robert F. Williams, Howard Hait, Freedolph D. Anderson, Walter H. Wilborn, Jeng Hsiu, Allison L. Thompson-Graves |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Ethinyl Estradiol-Norgestrel Combination medicine.medical_specialty Time Factors Adolescent medicine.drug_class Biopsy media_common.quotation_subject Population Urology Endometrium Cohort Studies Ethinylestradiol medicine Humans Levonorgestrel education Menstrual cycle media_common Gynecology education.field_of_study business.industry Obstetrics and Gynecology Contraceptives Oral Synthetic Contraceptives Oral Combined Regimen medicine.anatomical_structure Reproductive Medicine Estrogen Hormonal contraception Female business medicine.drug |
| Zdroj: | Contraception. 71:55-59 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/j.contraception.2004.07.013 |
| Popis: | Objective To assess the effect on the endometrial microstructure of an extended-cycle oral contraceptive (OC) regimen containing ethinyl estradiol (EE) and levonorgestrel (LNG). Methodology Subjects received up to four cycles of a 91-day extended-cycle OC regimen (84 consecutive days of monophasic 30 μg EE/150 μg LNG followed by 7 days of placebo). Endometrial biopsies were performed prior to the initiation and at the completion of therapy. All endometrial samples were processed centrally and reviewed by three independent pathologists blinded to treatment groups. Results Endometrial biopsies were performed in 50 women. In general, samples taken after completion of therapy with no further hormonal exposure demonstrated rapid return to normal endometrial cycling. In contrast, the majority of subjects still on active extended hormonal OC therapy at the time of biopsy had inactive or atrophic endometrium. No intravascular blood clots were observed in any of the specimens. Conclusion The endometrial findings observed in this cohort of women treated with a 91-day extended-cycle OC regimen for up to 1 year showed no significant pathology. Additionally, the endometrium reverted quickly to normal cyclic changes in those subjects who, after completing therapy, elected not to continue with hormonal contraception. |
| Databáze: | OpenAIRE |
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