Translational Investigation and Treatment of Neuropathic Pain
| Autor: | Hai-Rong Ye, Ying-Wei Wang, Bo Xu, Min Zhuo, Giannina Descalzi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Deep brain stimulation Neurology Gabapentin Pain medicine medicine.medical_treatment Pregabalin Review Translational Research Biomedical 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Physical medicine and rehabilitation lcsh:Pathology medicine Animals Humans 030304 developmental biology Analgesics 0303 health sciences business.industry Chronic pain medicine.disease 3. Good health Anesthesiology and Pain Medicine Neuropathic pain Neuralgia Molecular Medicine business 030217 neurology & neurosurgery lcsh:RB1-214 medicine.drug |
| Zdroj: | Molecular Pain Molecular Pain, Vol 8, Iss 1, p 15 (2012) |
| ISSN: | 1744-8069 |
| Popis: | Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play critical roles in neuropathic pain. Furthermore, descending facilitatory or excitatory modulation may also act to enhance chronic pain. Current clinical therapy for neuropathic pain includes the use of pharmacological and nonpharmacological (psychological, physical, and surgical treatment) methods. However, there is substantial need to better medicine for treating neuropathic pain. Future translational researchers and clinicians will greatly facilitate the development of novel drugs for treating chronic pain including neuropathic pain. |
| Databáze: | OpenAIRE |
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