Impaired response inhibition in obsessive compulsive disorder
| Autor: | Cristóbal Gastó, M. Salamero, Katya Rubia, Rafael Penadés, Rosa Catalán, S. Andrés |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder medicine.medical_specialty Stroop Paradigm Neuropsychological Tests Audiology Inhibitory postsynaptic potential behavioral disciplines and activities Functional Laterality Developmental psychology Discrimination Learning Thinking Orientation Reaction Time medicine Humans Attention Response inhibition Neuropsychology Cognition Middle Aged medicine.disease Inhibition Psychological Psychiatry and Mental health Cognitive inhibition Pattern Recognition Visual Female Psychology Psychomotor Performance Anxiety disorder Stroop effect |
| Zdroj: | European Psychiatry. 22:404-410 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2006.05.001 |
| Popis: | ObjectiveThe present study investigates different three inhibitory control functions in patients with obsessive-compulsive disorder (OCD). Selective motor response inhibition was tested in a GO/NO-GO paradigm, the inhibition of a triggered motor response in a STOP paradigm and the ability to inhibit cognitive interference in a motor STROOP paradigm.Methods27 patients who met DSM-IV criteria for OCD and 25 age, handedness and IQ-matched healthy control subjects were tested in the GO/NO-GO, STOP and motor STROOP tasks.ResultsOCD patients performed significantly worse than controls in the selective inhibition of their motor responses (GO/NO-GO) and in the inhibition of cognitive interference (STROOP), and also showed worse performance in suppressing previously triggered motor responses (STOP).ConclusionPatients with OCD are impaired in motor and cognitive inhibitory mechanisms. The findings are consistent with psychobiological and neuropsychological models of OCD suggesting impairment of frontostriatal circuitries that mediate functions of inhibitory control. |
| Databáze: | OpenAIRE |
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