Effects of Watermelon Powder and l -arginine Supplementation on Azoxymethane-Induced Colon Carcinogenesis in Rats
| Autor: | Keith Glenn, DawnKylee S. Klarich, Mark Kern, Shirin Hooshmand, Milica Kalaba, Arturo Figueroa, Mee Young Hong |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Arginine Colorectal cancer Azoxymethane Medicine (miscellaneous) Pharmacology Nitric Oxide Citrullus Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Aberrant Crypt Foci Animals Medicine neoplasms Nutrition and Dietetics business.industry Deoxyguanosine medicine.disease digestive system diseases Rats Colon carcinogenesis 030104 developmental biology Oncology chemistry 8-Hydroxy-2'-Deoxyguanosine Cyclooxygenase 2 030220 oncology & carcinogenesis Fruits and vegetables Colonic Neoplasms Dietary Supplements Powders business Precancerous Conditions DNA Damage |
| Zdroj: | Nutrition and Cancer. 70:938-945 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | Diets high in fruits and vegetables may help prevent colorectal cancer (CRC). Watermelon consumption may reduce CRC risk due to its concentration of l-citrulline and its role in endothelial nitric oxide (NO) production. Research suggests that increased NO levels have tumoricidal effects. The purpose of this study was to determine the effects of watermelon powder supplementation on aberrant crypt foci (ACF) formation, precancerous lesions, and expression of genes associated with colon carcinogenesis. Thirty-two male Sprague-Dawley rats were assigned into three groups: control, 0.36% l-arginine, or 0.5% watermelon powder and injected with azoxymethane (15 mg/kg body weight). Both l-arginine and watermelon powder groups exhibited lower total numbers of ACF and high multiplicity ACF (P 0.01). The watermelon powder group exhibited higher NO levels and lower 8-hydroxyguanosine DNA damage (P 0.05). Watermelon powder and l-arginine downregulated 8-oxoguanine DNA glycosylase gene expression and upregulated O |
| Databáze: | OpenAIRE |
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