CCKB receptor activation protects CA1 neurons from ischemia-induced dysfunction in stroke-prone spontaneously hypertensive rats hippocampal slices
| Autor: | Kazuo Kawasaki, Mitsuru Yasui |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Hippocampus In Vitro Techniques Hippocampal formation Devazepide digestive system Neuroprotection Sincalide Brain Ischemia Rats Inbred SHR Internal medicine medicine Extracellular Animals Stroke Neurons Benzodiazepinones business.industry General Neuroscience digestive oral and skin physiology Population spike medicine.disease In vitro Rats Electrophysiology Cerebrovascular Disorders Endocrinology Potassium Receptors Cholecystokinin business Neuroscience hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroscience Letters. 191:99-102 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(95)11570-0 |
| Popis: | We examined the effect of cholecystokinin octapeptide sulfated type (CCK-8S) on dysfunction of CA1 pyramidal neurons induced by in vitro ischemic insult in hippocampal slices of stroke-prone spontaneously hypertensive rats (SHRSP). CCK-8S shortened the time required for partial recovery from block of a population spike produced by ischemia. Furthermore. CCK-8S reduced ischemic insult-induced accumulation of K + in extracellular space. Suppression of the K + conductance by the CCK B receptor activation is suggested to contribute to neuroprotection by CCK-8S. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect