Treatment of primary progressive aphasias by transcranial direct current stimulation combined with language training
| Autor: | Barbara Borroni, Maura Cosseddu, Michela Brambilla, Michela Petesi, Maria Cotelli, Alessandro Padovani, Orazio Zanetti, Rosa Manenti, Carlo Miniussi |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty non-invasive brain stimulation medicine.medical_treatment Audiology Placebo frontotemporal dementia rehabilitation Primary progressive aphasia Aphasia medicine Humans Neuropsychological assessment Aged Rehabilitation medicine.diagnostic_test Transcranial direct-current stimulation General Neuroscience General Medicine Middle Aged medicine.disease Combined Modality Therapy Transcranial Magnetic Stimulation Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Aphasia Primary Progressive Treatment Outcome Brain stimulation Scalp Language Therapy Female Geriatrics and Gerontology medicine.symptom Psychology Neuroscience Follow-Up Studies |
| Popis: | Background Primary progressive aphasia (PPA) is an untreatable neurodegenerative disorder that disrupts language functions. Previous studies have demonstrated transcranial direct current stimulation (tDCS) may improve language symptoms in patients with post stroke aphasia or neurodegenerative diseases. Objective The present study investigated whether the application of anodal tDCS (AtDCS) to the scalp overlying the left dorsolateral prefrontal cortex (DLPFC), which may increase cortical excitability, in combination with individualized speech therapy would improve naming accuracy in the agrammatic variant of PPA (avPPA). Methods Sixteen avPPA patients were randomly allocated into two subgroups: AtDCS (n = 8) or placebo tDCS (PtDCS). tDCS was applied over the left DLPFC (BA 8/9) 25 minutes per day for two weeks (10 days). Each patient underwent 25 minutes of individualized speech therapy with either AtDCS or PtDCS during each treatment session. Neuropsychological assessment, experimental naming, and linguistic abilities in daily living were assessed at baseline (T0), after two weeks of intervention (T1) and at a 12-week follow-up (T2). Results Significant improvement in experimental naming was observed in both groups at T1 and T2, but this effect was significantly greater in AtDCS than PtDCS patients. Naming correctness, as assessed using the Aachener Aphasie Test, increased selectively in the AtDCS group from T0 to T1, and this effect remained significant at T2. The analysis of daily living language abilities improved selectively in AtDCS group. Conclusion Our results support the beneficial effect of targeted language training in combination with brain stimulation in avPPA patients. tDCS should be considered a useful tool for the improvement of language functions in patients with neurodegenerative diseases in future trials. |
| Databáze: | OpenAIRE |
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