Mitochondrial Dysfunction in Drug-Induced Liver Injury
| Autor: | Annie Borgne-Sanchez, Bernard Fromenty |
|---|---|
| Přispěvatelé: | Mitologics S.A.S., Hôpital Robert Debré Paris, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Hepatitis
Liver injury Drug 0303 health sciences Steatosis Drug-induced liver injury business.industry media_common.quotation_subject [SDV]Life Sciences [q-bio] Hepatotoxicity Pharmacology Mitochondrion medicine.disease 3. Good health Mitochondria 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine business 030304 developmental biology media_common |
| Zdroj: | Mitochondrial Dysfunction in Drug-Induced Liver Injury Mitochondrial Dysfunction in Drug-Induced Liver Injury, 1-2, wiley, pp.47-72, 2018, 9781119329725; 9781119329701. ⟨10.1002/9781119329725.ch5⟩ Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants |
| Popis: | International audience; Mitochondrial dysfunction is a major mechanism whereby different drugs can induce liver injury such as cytolytic hepatitis, microvesicular and/or macrovacuolar steatosis, steatohepatitis, and possibly cholestasis. In the most severe cases, drug-induced mitochondrial dysfunction and liver injury can require liver transplantation or lead to the death of the patient. Moreover, these adverse effects can lead to the withdrawal of drugs from the market, or earlier during clinical trials. Drugs can induce mitochondrial dysfunction by different mechanisms including inhibition of fatty acid oxidation, impairment of oxidative phosphorylation and respiratory chain activity, and alteration of the integrity of the mitochondrial membranes. The present chapter focuses on different drugs for which enough clinical and experimental evidence indicates the potential role of mitochondrial dysfunction in the pathogenesis of liver injury acetaminophen, amiodarone, fialuridine, linezolid, nucleoside reverse transcriptase inhibitors (e.g., stavudine, zidovudine, and didanosine), tamoxifen, tetracycline, troglitazone, and valproic acid. Because drug-induced mitochondrial dysfunction and liver injury are major issues for public health and pharmaceutical companies, mitochondrial liability should be systematically investigated during preclinical safety studies. © 2018 John Wiley and Sons, Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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