Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort

Autor: Howard N. Hodis, John T. Brooks, Kenneth A. Lichtenstein, Matthew J. Budoff, Nur F. Önen, Pragna Patel, Eleanor Wilson, Jason V. Baker, Erna M. Kojic, Katherine Huppler Hullsiek, Amrit Singh, Keith Henry, Irini Sereti
Rok vydání: 2014
Předmět:
Male
Oncology
HIV Infections
Coronary Artery Disease
Disease
Cardiovascular
Medical and Health Sciences
Cohort Studies
Coronary artery disease
cardiovascular disease
Leukocytes
Immunology and Allergy
Prospective Studies
Prospective cohort study
Biological Sciences
Middle Aged
Flow Cytometry
Coronary Vessels
Heart Disease
Infectious Diseases
Cohort
HIV/AIDS
Female
Cohort study
Adult
medicine.medical_specialty
CD14
Mononuclear
Immunology
Peripheral blood mononuclear cell
immune activation
monocyte activation
Article
Immunophenotyping
Clinical Research
Virology
Internal medicine
medicine
Humans
Heart Disease - Coronary Heart Disease
coronary artery calcium
business.industry
Prevention
Psychology and Cognitive Sciences
HIV
Odds ratio
medicine.disease
CDC SUN Study Investigators
Good Health and Well Being
inflammation
Leukocytes
Mononuclear
Calcium
business
Zdroj: AIDS (London, England), vol 28, iss 6
ISSN: 0269-9370
DOI: 10.1097/qad.0000000000000145
Popis: Background: Identifying immunologic mechanisms that contribute to premature cardiovascular disease (CVD) among HIV-positive patients will inform prevention strategies. Methods: Coronary artery calcium (CAC) progression was studied in an HIV cohort. Immunophenotypes were measured on baseline cryopreserved peripheral blood mononuclear cells using multicolor flow cytometry. Logistic regression identified predictors of CAC progression after adjusting for traditional and HIV-related risk factors. Results: Baseline characteristics for the analysis cohort (n = 436) were median age 42 years, median CD4+ cell count 481 cells/μl, and 78% receiving antiretroviral therapy. Higher frequencies of CD16+ monocytes were associated with greater likelihood of CAC progression, after adjusting for traditional and HIV risk factors [odds ratio per doubling was 1.66 for CD14+/CD16+ (P = 0.02), 1.36 for CD14dim/CD16+ (P = 0.06), and 1.69 for CD14var/CD16+ (P = 0.01)]. Associations for CD16+ monocytes persisted when restricted to participants with viral suppression. We found no significant associations for CAC progression with other cellular phenotypes, including T-cell activation and senescence markers. Conclusion: Circulating CD16+ monocytes, potentially reflecting a more pro-atherogenic subpopulation, independently predicted greater CAC progression among HIV-infected persons at low risk for AIDS. In contrast to T-cell abnormalities classically associated with AIDS-related disease progression, these data highlight the potential role of monocyte activation in HIV-related CVD risk.
Databáze: OpenAIRE
Externí odkaz: