Creatine kinase as a marker of obesity in a multi-ethnic population
| Autor: | Inge Oudman, Lizzy M. Brewster, Frederieke S. Diemer, Fares A. Karamat, Gert A. van Montfrans, Yentl C. Haan, Irene G. M. van Valkengoed |
|---|---|
| Přispěvatelé: | Graduate School, Vascular Medicine, ANS - Neurovascular Disorders, ACS - Amsterdam Cardiovascular Sciences, APH - Methodology, APH - Health Behaviors & Chronic Diseases, Public and occupational health, ARD - Amsterdam Reproduction and Development, ACS - Pulmonary hypertension & thrombosis, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, ACS - Microcirculation |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Waist Population 030204 cardiovascular system & hematology Biochemistry Body Mass Index 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Risk Factors Internal medicine Ethnicity Medicine Humans Obesity education Prospective cohort study Molecular Biology Creatine Kinase Exercise education.field_of_study biology business.industry Waist-Hip Ratio Skeletal muscle Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies biology.protein Creatine kinase Female Insulin Resistance Waist Circumference business Energy Metabolism Body mass index Biomarkers |
| Zdroj: | Molecular and cellular endocrinology, 442(C), 24-31. Elsevier Ireland Ltd |
| ISSN: | 0303-7207 |
| Popis: | Creatine kinase (CK), the central regulatory enzyme of energy metabolism, is particularly high in type II skeletal muscle fibers, which are associated with insulin resistance and obesity. As resting plasma CK is mainly derived from skeletal muscle, we assessed whether plasma CK is associated with markers of obesity. In this cross-sectional study, we analyzed a random sample of the multi-ethnic population of Amsterdam, the Netherlands, consisting of 1444 subjects aged 34-60 years. The primary outcome was the independent association between plasma CK after rest and waist circumference. Other outcomes included waist-to-hip ratio and body mass index. Mean waist circumference increased from the first through the third CK tertile, respectively 90.3 (SD 13.4), 93.2 (SD 14.3), and 94.4 (SD 13.3) cm (p < 0.001 for differences between tertiles). The increase in waist circumference was 8.91 (95% CI 5.35 to 12.47) cm per log CK increase after adjustment for age, sex, African ethnicity, educational level, physical activity and plasma creatinine. Similarly, CK was independently associated with waist-to-hip ratio and body mass index, with an increase of respectively 0.05 (95% CI 0.03 to 0.07) and 3.6 (95% CI 2.3 to 5.0) kg/m(2) per log CK increase. Plasma CK is independently associated with measures of obesity in a multi-ethnic population. This is in line with the central role of type II skeletal muscle fibers in energy metabolism and obesity. Prospective studies should assess whether resting plasma CK could be an easy accessible marker of CK rich type II fiber predominance that helps identify individuals at risk for obesity |
| Databáze: | OpenAIRE |
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