Amoxicillin Pharmacokinetics in (Preterm) Infants Aged 10 to 52 Days: Effect of Postnatal Age
| Autor: | M.G. Driessen, F.H. van Tiel, Luc J. I. Zimmermann, Joyce Pullen, Leo M L Stolk, Cees Neef, Pieter L.J. Degraeuwe |
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| Přispěvatelé: | Huisartsgeneeskunde, Farmacologie & Toxicologie, Kindergeneeskunde, Medische Microbiologie, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: GROW - School for Oncology and Reproduction |
| Rok vydání: | 2007 |
| Předmět: |
Male
Aging medicine.medical_specialty Metabolic Clearance Rate Gastroenterology Pharmacokinetics Elimination rate constant Intensive Care Units Neonatal Internal medicine medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology Volume of distribution medicine.diagnostic_test business.industry Body Weight Infant Newborn Amoxicillin Infant Gestational age Anti-Bacterial Agents Postnatal age Therapeutic drug monitoring Anesthesia Female Drug Monitoring business Infant Premature medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring, 29(3), 376-380. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/ftd.0b013e318067de5c |
| Popis: | The pharmacokinetic parameters of amoxicillin were determined in 32 newborn infants aged 10 to 52 days (mean postnatal age, 24.7 +/- 12.4 days) to improve amoxicillin dosing in this age group. Amoxicillin plasma concentrations were determined using reversed-phase high-performance liquid chromatography in surplus plasma samples from routine gentamicin assays. Amoxicillin pharmacokinetic parameters (mean +/- SD) were as follows: first-order elimination constant (K(el)) = 0.27 +/- 0.10 h(-1), volume of distribution corrected for body weight (V/W) = 0.66 +/- 0.27 L/kg, total body clearance corrected for body weight (CL/W) = 0.18 +/- 0.10 Lkg(-1)h(-1), and elimination half-life (t(1/2)) = 3.0 +/- 1.3 hours. Amoxicillin body clearance was approximately twofold greater in our patients compared with published values in younger neonates (mean postnatal age, 0.76 +/- 1.57 days). Simulation studies using the observed amoxicillin pharmacokinetic data suggest an amoxicillin dose of 40 mg/kg administered every 8 hours in infants older than 9 days postnatal age, independent of gestational age and postconceptional age, to achieve satisfactory target plasma amoxicillin concentrations less than 140 mg/L and time above minimum inhibitory concentration of at least 40%. Prospective evaluation of this suggested new dosage regimen is necessary before implementation in the care of ill neonates. |
| Databáze: | OpenAIRE |
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