Clinical Effectiveness of Maintenance Electroconvulsive Therapy in Patients with Schizophrenia: A Retrospective Cohort Study
| Autor: | Daniel M. Blumberger, Jesse Remington, Zafiris J. Daskalakis, Moshe Isserles, Tyler S. Kaster |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty medicine.medical_treatment Neuroscience (miscellaneous) Schizoaffective disorder Neuropsychological Tests Article 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy medicine Humans Antipsychotic Adverse effect Electroconvulsive Therapy Aged Retrospective Studies Aged 80 and over Ontario business.industry Retrospective cohort study Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Treatment Outcome Tolerability Psychotic Disorders Schizophrenia Female business 030217 neurology & neurosurgery Diagnosis of schizophrenia |
| Zdroj: | J ECT |
| Popis: | Objective This study aimed to assess the clinical effectiveness and cognitive effects of maintenance electroconvulsive therapy (mECT) in patients with schizophrenia or schizoaffective disorder and explore factors associated with both outcomes. Methods In this retrospective cohort study, we examined clinical records of 47 patients with a Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnosis of schizophrenia or schizoaffective disorder treated with mECT at an academic mental health hospital between April 2010 and July 2016. Sixty-two mECT courses were reviewed. We assessed clinical effectiveness and cognitive effects as well as factors associated with response to treatment, including psychiatric diagnosis, concomitant pharmacological treatment, and previous treatment response. Results Maintenance electroconvulsive therapy was able to maintain clinical response in 48 (77%) treatment courses. Significant cognitive adverse effects were reported in 7 (11%) of the courses. Use of antipsychotic, antidepressant or benzodiazepine medications, psychiatric disorder, and sex were not associated with response. Conclusion This study shows meaningful clinical effectiveness and good tolerability of mECT in patients with resistant schizophrenia over extended periods. |
| Databáze: | OpenAIRE |
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