Jitter evaluation in denervation and reinnervation in 32 cases of chronic radiculopathy
| Autor: | Felipe Oliveira de Faria, Joao Aris Kouyoumdjian, Luis Guilherme Ronchi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
animal structures Neuromuscular junction Single-fiber electromyography Jitter lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Myosin otorhinolaryngologic diseases medicine Muscle membrane lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Acetylcholine receptor Denervation business.industry 030208 emergency & critical care medicine Fibrillation potentials medicine.anatomical_structure Concentric needle electrode Neurology Clinical and Research Article Cardiology Neurology (clinical) business 030217 neurology & neurosurgery Reinnervation |
| Zdroj: | Clinical Neurophysiology Practice Clinical Neurophysiology Practice, Vol 5, Iss, Pp 165-172 (2020) |
| ISSN: | 2467-981X |
| Popis: | Highlights • The mean jitter is increased in all muscles with fibrillation potentials. • The mean jitter is increased by about 75% of muscles with chronic denervation only. • Activity in chronic denervated muscles could retain immature atrophic muscle fibers. Objective To measure the jitter parameters in muscles with denervation/reinnervation in 32 chronic radiculopathy cases. Methods Measurements were done in chronic denervated muscles by voluntary and electrical activation using a concentric needle electrode. Results Mean jitter was abnormal in 87.5% (mean 49.2 µs) and 81.25% (mean 36.8 µs), for voluntary and electrical activation. In muscles with fibrillation potentials (FPs), the mean jitter was abnormal in all cases, and impulse blocking was frequent (53.4–92.3%). In muscles without FPs, the mean jitter was abnormal in 78.9% for voluntary activation and 68.4% for electrical activation. No correlation was found between jitter and motor unit action potential amplitude. Conclusion The muscles with FPs were associated with the immature spread of acetylcholine receptors (AChRs) throughout the muscle membrane. Conversely, the neuromuscular junctions (NMJs) assemble may be repressed by the already reinnervated muscles. For those, higher jitter may be due to the persistence of atrophic fibers expressing neonatal myosin heavy chain (MHC) and immaturity of NMJ composting instead of the overspread of immature AChRs. Significance Jitter measurement must be avoided in chronic denervated muscles, regardless of FPs’ presence. The activity of reinnervated muscle could maintain neonatal MHC and repress new NMJs development. |
| Databáze: | OpenAIRE |
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