Emerging technologies in hemostasis diagnostics: a report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group
| Autor: | Chris Ward, Emma Perrin, Mark P Smith, Alessandra Bianchi, Douglas Coghlan, Murray J. Adams, J. Thom |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Diagnostic methods Emerging technologies ADAMTS13 Protein Thrombophilia Fibrin Fibrinogen Degradation Products Molecular typing Risk Factors medicine Humans Intensive care medicine Blood Coagulation Blood coagulation test Hemostasis Australasia business.industry Clinical Laboratory Techniques Thrombosis Hematology Blood Coagulation Disorders medicine.disease Thrombelastography ADAM Proteins Anticoagulant therapy Chemistry Clinical Immunology Blood Coagulation Tests Cardiology and Cardiovascular Medicine business |
| Zdroj: | Seminars in thrombosis and hemostasis. 33(3) |
| ISSN: | 0094-6176 |
| Popis: | Technology in hemostasis laboratories has evolved enormously during the last 30 years. Although many scientists and clinicians will remember the traditional tilt-tube techniques to screen for coagulation abnormalities and to monitor anticoagulant therapy, the hemostasis laboratory today uses a variety of modern technologies. These include flow cytometry, chromogenic assays, molecular typing (e.g., polymerase chain reaction), immunologic assays (e.g., enzyme-linked immunosorbent assays), functional assays of specific coagulation proteins, and platelet function analyzers. Although these advances in technology have resulted in greater capability, productivity, sensitivity, specificity, and ultimately, improvement in the clinical care of patients, controversies and limitations remain. This article highlights new and emerging technologies in hemostasis and discusses whether they have improved or are likely to improve laboratory diagnostics by specifically addressing the following: (1) Can new technologies help predict likelihood of thrombosis recurrence? (2) Has an understanding of the role of A Disintegrin-like And Metalloprotease with Thrombo Spondin type 1 motifs (ADAMTS13) in microangiopathy resulted in improved diagnostic methods for this disorder? (3) Does thrombelastography allow better definition of bleeding risk than conventional hemostasis assays, especially in settings of acute hemostatic pathology? |
| Databáze: | OpenAIRE |
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